Abstract In this article, Au nanoparticles (AuNPs) were deposited on carboxylated graphene oxide (GO-COOH) for the electrochemical oxidation and enzyme-free voltammetric and amperometric determination of glucose. The GO-COOAu modified glassy carbon electrode (GCE) exhibited good sensitivity and stability toward glucose electro-oxidation in alkaline media. The surface morphology of the as-prepared nanocomposite was investigated by field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). The electrochemical characterization of the working electrodes was evaluated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and amperometry. The GO-COOAu/GCE sensor provided excellent electro-catalytic performance for glucose oxidation with a linear range from 0.02 to 4.48 mM (R2 = 0.9919) at +0.35 V, a low limit of detection (LOD) of 6 μM, and a high sensitivity of 20.218 μA mM−1 cm−2. The GO-COOAu nanocomposite modified working electrode with high sensitivity, repeatability, reproducibility, and quantification of glucose in human serum samples made it a promising material for the development of non-enzymatic sensors.

中文翻译：

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基于沉积在羧化氧化石墨烯上的金纳米颗粒的非酶葡萄糖传感器的制造

摘要 在本文中，Au 纳米粒子 (AuNPs) 沉积在羧化氧化石墨烯 (GO-COOH) 上，用于葡萄糖的电化学氧化和无酶伏安法和电流法测定。GO-COOAu修饰的玻碳电极（GCE）在碱性介质中对葡萄糖电氧化表现出良好的敏感性和稳定性。通过场发射扫描电子显微镜 (FESEM) 和 X 射线衍射 (XRD) 研究了所制备的纳米复合材料的表面形貌。使用循环伏安法 (CV)、电化学阻抗谱 (EIS) 和电流分析法评估工作电极的电化学特性。GO-COOAu/GCE 传感器为葡萄糖氧化提供了出色的电催化性能，在 +0.35 V 下线性范围为 0.02 至 4.48 mM（R2 = 0.9919），6 μM 的低检测限 (LOD) 和 20.218 μA mM-1 cm-2 的高灵敏度。GO-COOAu 纳米复合材料修饰的工作电极具有高灵敏度、可重复性、再现性和人血清样品中葡萄糖的定量，使其成为开发非酶传感器的有前途的材料。