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How do lipid nanocarriers - Cubosomes affect electrochemical properties of DMPC bilayers deposited on gold (111) electrodes?
Bioelectrochemistry ( IF 4.8 ) Pub Date : 2020-03-20 , DOI: 10.1016/j.bioelechem.2020.107516 Julia Alvarez-Malmagro 1 , Elżbieta Jablonowska 1 , Ewa Nazaruk 1 , Piotr Szwedziak 2 , Renata Bilewicz 1
Bioelectrochemistry ( IF 4.8 ) Pub Date : 2020-03-20 , DOI: 10.1016/j.bioelechem.2020.107516 Julia Alvarez-Malmagro 1 , Elżbieta Jablonowska 1 , Ewa Nazaruk 1 , Piotr Szwedziak 2 , Renata Bilewicz 1
Affiliation
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Cubosome nanocarriers are promising biomimetic drug delivery systems used in particular for highly toxic drugs in cases where decreasing unwanted side effects is especially important. The properties of electrode supported lipid bilayer prepared by the combined Langmuir-Blodgett and Langmuir-Schaefer techniques were studied using electrochemical techniques following exposure of the film - covered electrode to a solution containing phytantriol - based cubosomes. The inclusion of the carrier in the model membrane under different experimental conditions was probed and the modifications induced in the lipid organization were for the first time inferred by quantitative analysis of the responses of cyclic voltammetry (CV), AC voltammetry and Electrochemical Impedance Spectroscopy (EIS) as well as blocking assays using a redox probe in the solution. Exposure of a preformed DMPC bilayer to cubosome solution resulted in the improved barrier properties of the film reflecting disintegration of cubosomes and formation of additional phytantriol/Pluronic F-108 polymer layer on the top of the DMPC bilayer. On the other hand, formation of the layer in the presence of cubosomes in the subphase lead to an increased capacitance of the film since penetration of the lipid layers by the cubosomal phytantriol increased the porosity of the film.
中文翻译：
脂质纳米载体-脂质体如何影响沉积在金（111）电极上的DMPC双层的电化学性质？
在减少不良副作用尤为重要的情况下，立方体纳米载体是有前途的仿生药物递送系统，尤其适用于高毒性药物。在覆盖膜的电极暴露于含有植物三醇的立方脂质体的溶液中之后，使用电化学技术研究了由Langmuir-Blodgett和Langmuir-Schaefer组合技术制备的电极支撑脂质双层的性能。探索了在不同实验条件下模型膜中载体的包含情况，并通过定量分析循环伏安法（CV），交流伏安法和电化学阻抗谱（EIS）的反应首次推断了脂质组织中引起的修饰）以及使用溶液中的氧化还原探针进行的封闭分析。将预先形成的DMPC双层暴露于立方溶液中，会导致薄膜的阻隔性能得到改善，这反映了立方微粒的崩解并在DMPC双层的顶部形成了额外的植物三醇/ Pluronic F-108聚合物层。另一方面，在亚相中存在立方脂质体的情况下形成该层导致膜的电容增加，这是因为立方脂质体植物三醇对脂质层的渗透增加了膜的孔隙率。
更新日期：2020-03-20
中文翻译：
脂质纳米载体-脂质体如何影响沉积在金（111）电极上的DMPC双层的电化学性质？
在减少不良副作用尤为重要的情况下，立方体纳米载体是有前途的仿生药物递送系统，尤其适用于高毒性药物。在覆盖膜的电极暴露于含有植物三醇的立方脂质体的溶液中之后，使用电化学技术研究了由Langmuir-Blodgett和Langmuir-Schaefer组合技术制备的电极支撑脂质双层的性能。探索了在不同实验条件下模型膜中载体的包含情况，并通过定量分析循环伏安法（CV），交流伏安法和电化学阻抗谱（EIS）的反应首次推断了脂质组织中引起的修饰）以及使用溶液中的氧化还原探针进行的封闭分析。将预先形成的DMPC双层暴露于立方溶液中，会导致薄膜的阻隔性能得到改善，这反映了立方微粒的崩解并在DMPC双层的顶部形成了额外的植物三醇/ Pluronic F-108聚合物层。另一方面，在亚相中存在立方脂质体的情况下形成该层导致膜的电容增加，这是因为立方脂质体植物三醇对脂质层的渗透增加了膜的孔隙率。
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