Macroporous resin technology has unique advantages in the effective separation and purification of components from natural product. Evaluation of adsorption and desorption ability of chlorogenic acid on ten kinds of macroporous resins (AB-8, D4020, HPD-722, HPD-300, HPD-100, NKA, NKA-Ⅱ, NKA-9, S-8, X-5) from Eucommia ulmoides Oliv. leaves extraction was carried in this study. Resin NKA-Ⅱ exhibited the highest adsorption and desorption capacity and recovery. The adsorption parameters of NKA-Ⅱ resin for chlorogenic acid can be accurately calculated with the Freundlich equation. The adsorption process was observed following a pseudo-second-order kinetic model. Dynamic testing was performed on a NKA-Ⅱ resin-packed column where the breakthrough point was identified at four bed volumes of extract was loaded, and five bed volumes of 70% ethanol was required for complete desorption. After enrichment with macroporous adsorbent resin, the content of chlorogenic acid from extract increased 6.21-fold from 1.9% to 11.8%. The recovery of chlorogenic acid reached 87.9%.

大孔树脂技术在有效分离和纯化天然产物中的成分方面具有独特优势。绿原酸在十种大孔树脂（AB-8，D4020，HPD-722，HPD-300，HPD-100，NKA，NKA-Ⅱ，NKA-9，S-8，X- 5）来自杜仲奥利夫 在这项研究中进行了叶提取。树脂NKA-Ⅱ具有最高的吸附解吸能力和回收率。利用Freundlich方程可以准确地计算NKA-Ⅱ树脂对绿原酸的吸附参数。遵循伪二级动力学模型观察吸附过程。在装有NKA-Ⅱ树脂的色谱柱上进行动态测试，在该色谱柱上确定了在四个床体积的萃取液中确定的突破点，并且需要五个床体积的70％乙醇才能完全脱附。用大孔吸附树脂富集后，提取物中的绿原酸含量从1.9％增加到11.8％，增加了6.21倍。绿原酸的回收率达到87.9％。