Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii,Phytochemistry

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Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii
Phytochemistry ( IF 3.2 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.phytochem.2020.112343
Lulu Li ₁ , Long Chen ₁ , Yuhuan Li ₂ , Shikai Sun ₁ , Shuanggang Ma ₁ , Yong Li ₁ , Jing Qu ₁

Affiliation

Detailed phytochemical investigation of the roots of Erythrophleum fordii furnished seven undescribed cassane-type diterpenoids, erythrocassanoids A-E and erythro-norcassanoids A, B and two known clerodane diterpenes, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid. Their structures were determined by 1D, 2D NMR and HRESIMS analysis. The antiviral activities of these compounds were evaluated. Among them, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid showed antiviral activities against influenza virus and coxsackie virus with IC50 values ranging from 11.11 to 29.60 μM.

中文翻译：

来自 Erythrophleum fordii 根的卡桑和正卡桑二萜

对 Erythrophleum fordii 根的详细植物化学研究提供了七种未描述的 cassane 型二萜、erythrocassanoids AE 和 erythro-norcassanoids A、B 和两种已知的 clerodane 二萜、15-hydroxy-3-cleroden-2-one 和 2-oxopopuli 的甲酯酸。它们的结构由一维、二维核磁共振和 HRESIMS 分析确定。评价了这些化合物的抗病毒活性。其中，15-hydroxy-3-cleroden-2-one 和 2-oxopopulifolic 酸甲酯对流感病毒和柯萨奇病毒具有抗病毒活性，IC50 值为 11.11 至 29.60 μM。

更新日期：2020-06-01

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