Siphonagarofurans A-J: Poly-O-acylated β-dihydroagarofuran sesquiterpenoids from the fruits of Siphonodon celastrineus,Phytochemistry

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Siphonagarofurans A-J: Poly-O-acylated β-dihydroagarofuran sesquiterpenoids from the fruits of Siphonodon celastrineus
Phytochemistry ( IF 3.2 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.phytochem.2020.112345
Suriphon Singha ₁ , Pathumwadee Yotmanee ₁ , Jantana Yahuafai ₂ , Pongpun Siripong ₂ , Samran Prabpai ₃ , Somyote Sutthivaiyakit ₁

Affiliation

Ten poly-O-acylated β-dihydroagarofuran sesquiterpenoids, siphonagarofurans A-J, were obtained from the fruits of Siphonodon celastrineus using chromatographic techniques. Their structures were elucidated by extensive use of 2-D NMR spectroscopic methods. The absolute configurations of siphonagarofurans A-J were assigned following analysis of calculated and experimental ECD spectra. The absolute configuration of siphonagarofuran A was also confirmed by X-ray crystallographic analysis. Selected compounds were evaluated for their cytotoxic activity against KB, Vero and Hela cell lines with siphonagarofuran J identified as the most active compound, with IC50 values ranging from 14 to 27 μM.

中文翻译：

Siphonagarofurans AJ：来自 Siphonodon celastrineus 果实的聚-O-酰化 β-二氢琼脂呋喃倍半萜类化合物

使用色谱技术从 Siphonodon celastrineus 的果实中获得了 10 种聚 O-酰化 β-二氢琼脂呋喃倍半萜类化合物，siphonagarofurans AJ。通过广泛使用二维核磁共振光谱方法阐明了它们的结构。在对计算的和实验的 ECD 光谱进行分析之后，分配了虹吸隆呋喃 AJ 的绝对构型。siphonagarofuran A 的绝对构型也通过 X 射线晶体学分析得到证实。选定化合物对 KB、Vero 和 Hela 细胞系的细胞毒活性进行了评估，其中虹吸隆呋喃 J 被确定为最具活性的化合物，IC50 值范围为 14 至 27 μM。

更新日期：2020-06-01

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