To systematically regulate new types of cigarettes for which their safety has yet to be verified, such as heat-not-burn (HNB) products and electronic cigarettes (E-Cigs), the identification of chemicals in the new cigarette smoke is necessary. However, this is challenging due to the large number of new cigarette types and their different vaporization approaches. To address this issue, we herein report the development of a standardized new cigarette smoke generating (SNCSG) system based on heating-temperature control, which is able to generate smoke for all types of new cigarettes. Validation of the developed system was also carried out through analysis of the carbonyl compounds (e.g., formaldehyde and acetaldehyde) in the new cigarette smoke of HNB products and E-Cigs generated by the SNCSG system under different heating temperatures. The analytical results were used to validate the SNCSG system by comparison with those of previous studies. In all new cigarette smoke samples, the formaldehyde and acetaldehyde concentrations increased dramatically upon increasing the heating temperatures, especially over the reference heating range of each HNB device (mean concentration (μg/cigarette, n = 5 (HNB and E-Cig samples)): formaldehyde = 0.373-5.841 (250-320 °C), and acetaldehyde = 0.088-27.60 (250-320 °C). In the case of the HNB samples, the concentration differences determined by the heating temperatures of the tobacco stick were statistically significant, with p-values (ANOVA) of 1.85E-10 (formaldehyde) and 1.73E-08 (acetaldehyde). In the majority of smoke samples, acrolein and propionaldehyde were detected under relatively high heating temperature conditions (>250 °C) at 0.50 ± 1.76 μg/(cigarette or 10 μL), while acetone was detected under low heating temperature conditions (<250 °C) at 0.09 ± 0.17 μg/(cigarette or 10 μL). These results indicate that the developed SNCSG system could be suitable for application in the regulation of new types of cigarettes, regardless of the cigarette type and heating approach.

中文翻译：

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开发标准化的新型卷烟烟雾生成（SNCSG）系统，以评估新型卷烟（热不燃烧（HNB）烟草和电子卷烟（E-Cigs））的烟雾中的化学物质。

为了系统地监管尚待验证其安全性的新型香烟，例如不燃烧（HNB）产品和电子香烟（E-Cigs），有必要对新型香烟烟雾中的化学物质进行识别。然而，由于大量的新型香烟及其不同的蒸发方法，这具有挑战性。为了解决这个问题，我们在此报告了一种基于加热温度控制的标准化新型香烟烟雾生成（SNCSG）系统的开发，该系统能够为所有类型的新型香烟生成烟雾。还通过分析在不同加热温度下由SNCSG系统生成的HNB产品和E-Cigs的新卷烟中的羰基化合物（例如甲醛和乙醛）中的羰基化合物（例如甲醛和乙醛）来验证开发的系统。通过与先前研究的比较，分析结果用于验证SNCSG系统。在所有新的香烟烟雾样品中，甲醛和乙醛的浓度随着加热温度的升高而急剧增加，尤其是在每个HNB设备的参考加热范围内（平均浓度（μg/根香烟，n = 5（HNB和E-Cig样品）） ：甲醛= 0.373-5.841（250-320°C），乙醛= 0.088-27.60（250-320°C）。对于HNB样品，通过烟草棒加热温度确定的浓度差异是统计上的显着，p值（ANOVA）为1.85E-10（甲醛）和1.73E-08（乙醛）。在大多数烟雾样品中，在相对较高的加热温度条件下（> 250°C）检测到丙烯醛和丙醛在0。50±1.76μg/（香烟或10μL），而丙酮在低加热温度条件（<250°C）下以0.09±0.17μg/（香烟或10μL）检测到。这些结果表明，无论卷烟类型和加热方式如何，开发的SNCSG系统都可适用于调节新型卷烟。