BACKGROUND Population aging is dynamic process of increasing proportion of older adults in the total population, which is an inescapable result of decline in fertility rate and extension in life expectancy. Inevitably, age-related metabolic diseases, for example obesity, type 2 diabetes, metabolic syndrome, dyslipidemia, and nonalcoholic fatty liver disease, are becoming epidemic globally along with the demographic transition. CONTENT The review examines the literatures related to: 1) the epidemiology of age related metabolic diseases including obesity, type 2 diabetes, metabolic syndrome, dyslipidemia, and nonalcoholic fatty liver disease; and 2) the risk factors of age related metabolic diseases including genetic factors, diet, smoking, Physical activity, intestinal microbiota and environmental factors. CONCLUSION Population aging is becoming epidemic worldwide, resulting in increasing incidence and prevalence of a serious of age-related metabolic diseases. Both genetic and environmental factors contribute to the diseases, thus interventions targeting on these factors may have beneficial effect on the development of age-related metabolic diseases.

中文翻译：

---

流行病学是与年龄有关的新陈代谢疾病的危险因素。

背景技术人口老龄化是增加老年人口在总人口中所占比例的动态过程，这是人口出生率下降和预期寿命延长的必然结果。不可避免地，与年龄相关的代谢性疾病，例如肥胖，2型糖尿病，代谢综合征，血脂异常和非酒精性脂肪肝，随着人口结构的转变，正在全球范围内流行。内容综述审查了与以下方面有关的文献：1）与年龄有关的代谢疾病的流行病学，包括肥胖，2型糖尿病，代谢综合征，血脂异常和非酒精性脂肪肝；2）与年龄有关的代谢性疾病的危险因素，包括遗传因素，饮食，吸烟，体育锻炼，肠道菌群和环境因素。结论人口老龄化正在全球范围内流行，导致严重的与年龄有关的代谢疾病的发生率和流行率增加。遗传因素和环境因素均导致该疾病，因此针对这些因素的干预措施可能会对与年龄有关的代谢性疾病的发展产生有益影响。