Prenatal stress (PNS) has its negative impact on both the infant hippocampal neurogenesis and pregnancy outcomes in the neonates that serves as a risk factor for postnatal depression in adult offsprings. Therefore, main objectives of the present study were to evaluate the effect of maternal chronic unpredictable mild stress (CUMS) on behavioural changes, levels of oxidative stress, changes in selective developmental signaling genes and neurogenesis in the adult brain of Wistar rats and its reversal through a selective non-ergoline D2 type dopamine receptor (D2R) agonist Ropinirole (ROPI). Effects of ROPI treatment on CUMS induced adult rats offspring were measured by assessment of behavioural tests (sucrose preference test and forced swim test), biomarkers of oxidative stress, protein expression of tyrosine hydroxylase (TH), mRNA expression of SHH, GSK-3β, β-catenin, Notch, brain-derived neurotrophic factor (BDNF), Dopamine receptor 2 (Drd2) and bromodeoxyuridine (BrdU) cell proliferation assay. The oxidative stress, protein and mRNA expression were determined in the hippocampus and prefrontal cortex while the BrdU cell proliferation was observed in the hippocampus of rat brain. PNS induced changes resulted in depression validated by the depression-like behaviours, increased oxidative stress, decreased TH expression, altered expression of selective developmental genes, along with the reduced hippocampal neurogenesis and BDNF expression in the brain of adult offsprings. Chronic ROPI treatment reversed those effects and was equally effective like Imipramine (IMI) treatment. So, the present study suggested that ROPI can be used as an antidepressant drug for the treatment of depressive disorders.

中文翻译：

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选择性D2多巴胺受体激动剂可通过上调酪氨酸羟化酶和增加产前应激大鼠海马的神经发生来缓解抑郁症。

产前压力（PNS）对新生儿的婴儿海马神经发生和妊娠结局均具有负面影响，这是成年后代产后抑郁的危险因素。因此，本研究的主要目的是评估母体慢性不可预测的轻度应激（CUMS）对Wistar大鼠成年大脑行为变化，氧化应激水平，选择性发育信号基因变化和神经发生的作用及其逆转的作用。选择性非麦角灵D2型多巴胺受体（D2R）激动剂罗匹尼罗（ROPI）。通过评估行为测试（蔗糖偏爱测试和强迫游泳测试），氧化应激的生物标记，酪氨酸羟化酶（TH）的蛋白表达，SHH的mRNA表达，评估ROPI处理对CUMS诱导的成年大鼠后代的影响。GSK-3β，β-catenin，Notch，脑源性神经营养因子（BDNF），多巴胺受体2（Drd2）和溴脱氧尿苷（BrdU）细胞增殖测定。测定大鼠海马和前额叶皮层的氧化应激，蛋白质和mRNA表达，同时观察大鼠脑海马中BrdU细胞的增殖。PNS诱导的变化导致抑郁，其通过抑郁样行为，氧化应激增加，TH表达降低，选择性发育基因的表达改变以及成年后代大脑中海马神经发生和BDNF表达减少而得到证实。长期ROPI治疗可逆转这些影响，并且与丙咪嗪（IMI）治疗同样有效。所以，