OBJECTIVE Absence status epilepticus (ASE) is a form of non-convulsive status epilepticus characterized by ongoing or intermittent epileptic activity accompanied by behavioral and cognitive changes. Herein, we assessed high-frequency oscillations in the ripple band in patients with ASE and typical absence seizures. METHODS We enrolled five patients with ASE, 26 patients with childhood absence epilepsy (CAE), and 15 patients with juvenile absence epilepsy (JAE). We performed time-frequency analysis of electroencephalogram data for ictal absence seizures at each electrode to assess the high frequency activity (HFA) rate, peak frequency, and peak power. RESULTS The average HFA rates were 60.7%, 20.8%, and 12.9% in ASE, CAE, and JAE patients, respectively. The average peak frequencies were 126.4 Hz, 120.9 Hz, and 126.1 Hz in ASE, CAE, and JAE patients, respectively. The average peak power values were 2,388.8 μV2, 120.9 μV2, and 126.1 μV2 in ASE, CAE, and JAE patients, respectively, and all epilepsy groups exhibited frontal-dominant ripple distribution. CONCLUSION ASE patients presented higher power and frontal dominant ripples of absence seizure, compared to CAE and JAE patients. SIGNIFICANCE Future studies should utilize scalp-recorded ripples as a biomarker of absence epilepsy. This may aid in the development of novel treatment strategies for ASE.

中文翻译：

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儿童期失神癫痫持续状态的高功率、额叶主导波纹

目的 失神性癫痫持续状态 (ASE) 是一种非惊厥性癫痫持续状态，其特征是持续或间歇性癫痫活动伴有行为和认知变化。在此，我们评估了 ASE 和典型失神发作患者的波纹带中的高频振荡。方法 我们招募了 5 名 ASE 患者、26 名儿童失神癫痫 (CAE) 患者和 15 名青少年失神癫痫 (JAE) 患者。我们对每个电极的发作性失神发作的脑电图数据进行时频分析，以评估高频活动 (HFA) 率、峰值频率和峰值功率。结果 ASE、CAE 和 JAE 患者的平均 HFA 发生率分别为 60.7%、20.8% 和 12.9%。ASE、CAE 和 JAE 患者的平均峰值频率分别为 126.4 Hz、120.9 Hz 和 126.1 Hz，分别。ASE、CAE 和 JAE 患者的平均峰值功率值分别为 2,388.8 μV2、120.9 μV2 和 126.1 μV2，并且所有癫痫组均表现出以额叶为主的纹波分布。结论 与 CAE 和 JAE 患者相比，ASE 患者表现出更高的力量和额叶主导的失神发作涟漪。意义 未来的研究应该利用头皮记录的涟漪作为失神癫痫的生物标志物。这可能有助于开发新的 ASE 治疗策略。意义 未来的研究应该利用头皮记录的涟漪作为失神癫痫的生物标志物。这可能有助于开发新的 ASE 治疗策略。意义 未来的研究应该利用头皮记录的涟漪作为失神癫痫的生物标志物。这可能有助于开发新的 ASE 治疗策略。