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Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups.
Molecular Cell ( IF 14.5 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.molcel.2020.02.025
Robert P Fisher 1
Affiliation  

In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.



中文翻译:

拼接或死亡:MYC行驶时,转录需要NUAK1以避免致命的堆积。

在此期《分子细胞》中,Cossa等人。(2020年)揭示了MYC失控的肿瘤细胞对激酶NUAK1依赖性的基础,该激酶通过PP1和PNUTS起作用,以确保剪接跟上MYC驱动的转录。

更新日期:2020-03-20
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