Background

Food can readily be tainted by pathogenic microorganisms, turning it into a stigmatized poison with potential harm to the consumer. To date, 31 identified and countless unidentified pathogens have been reported as accountable for foodborne illness globally. Approximately 66% of illnesses originate solely from pathogenic bacteria, and the association of these microorganisms in mono- and mixed-biofilms may increase bacterial intoxication and infection-linked problems in humans.

Scope and approach

Bacterial species live in close proximity to each other, share matrix components, and build three-dimensional rigid biofilm structures in nature. Due to their strong phenotypic heterogeneity and natural resistance to common sanitizers and disinfectants, mono- and mixed-bacterial biofilms can remain in food and on the surfaces of food processing appliances after sanitizing treatment. Green synthesis of “eco-friendly” anti-biofilm agents has become the necessary response to the occurrence of mono- and mixed-bacterial biofilms, in order to avoid the negative effects of conventional chemical and physical approaches on human health and the environment.

Key findings and conclusions

Advanced research has already proved the potential and efficacy of several microbe-derived anti-biofilm agents. This current review investigates the concerns associated with both mono- and mixed-bacterial biofilms and their control by biological anti-biofilm agents in different food industries. Moreover, this review highlights the recent achievements, existing limitations, and possible technical suggestions for further development of broad-spectrum microbe-derived anti-biofilm agents for the food industry.

中文翻译：

---

与老敌人作斗争：微生物衍生的生物制剂的承诺，将击败与食品工业有关的单细菌和混合细菌生物膜

背景

食物很容易被病原微生物污染，将其变成污名化的毒物，可能对消费者造成伤害。迄今为止，据报道全球已发现31种已查明和不计其数的未查明病原体。大约66％的疾病完全来自病原细菌，这些微生物在单生物膜和混合生物膜中的结合可能会增加细菌中毒和人类感染相关的问题。

范围和方法

细菌物种彼此紧邻，共享基质成分，并在自然界中构建三维刚性生物膜结构。由于它们强大的表型异质性和对普通消毒剂和消毒剂的天然抗性，经过消毒处理后，单细菌和混合细菌生物膜会残留在食品中以及食品加工设备的表面上。绿色合成的“生态友好型”抗生物膜剂已成为对单细菌和混合细菌生物膜发生的必要反应，以避免传统化学和物理方法对人类健康和环境的不利影响。

主要发现和结论

先进的研究已经证明了几种微生物衍生的抗生物膜剂的潜力和功效。本篇综述调查了与单细菌和混合细菌生物膜有关的问题，以及它们在不同食品行业中由生物抗生物膜剂控制的问题。此外，本综述重点介绍了食品工业广谱微生物衍生的抗生物膜剂的最新进展，存在的局限性以及可能的技术建议。