The research goal of the present study was to develop a carrier for loading and controlled -release of the hydrophobic drug with the combined use of organo-montmorillonite (OMMT) and alginate. The OMMT was synthesized through the intercalation modification of sodium montmorillonite (Na-MMT) with cationic cetyltrimethylammonium bromide (CTAB), nonionic nonylphenol polyoxyethylene ether (NPE) and the mixture of them via simple and convenient wet ball-milling method. Furthermore, the organo-montmorillonite/alginate (OMMT/Alg) composite hydrogel beads with slow and controlled release properties were constructed by using alginate as a coating material under the exogenous cross-linking of calcium ions. The physical and chemical properties of OMMT were comparatively evaluated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analyzer (TGA), BET-specific surface area measurements, and drug adsorption experiments. Experimental results showed that the presence of CTAB was able to facilitate the intercalation of CTAB/NPE into Na-MMT through the cation exchange reaction. And the cationic CTAB and nonionic NPE were adsorbed or intercalated into the MMT lamellar structure through the wet ball-milling process, which could change the hydrophilic nature of Na-MMT and improve its affinity to the hydrophobic drug molecules. In addition, the OMMT/Alg composite hydrogel beads displayed superior sustained-release properties than Na-MMT/Alg, mainly ascribed to the good affinity of OMMT to hydrophobic drug that retarded the drug diffusion. In particular, CTA/NPE-MMT/Alg with the highest loading capacity (LC) and encapsulation efficiency (EE) revealed the optimal controlled performance for the release of hydrophobic ibuprofen. The release followed the Korsmeyer-Peppas model suggested non-Fickian diffusion release mechanism. Based on the high drug loading capacity and excellent controlled drug release properties, the CTA/NPE-MMT/Alg incorporating hydrophobic drugs into hydrophilic matrices could be a highly promising material for use in hydrophobic drug delivery.

中文翻译：

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CTAB和NPE改性的有机蒙脱土的合成和评估，用于制造基于有机蒙脱土/藻酸盐的疏水性药物控释制剂。

本研究的研究目标是开发一种结合有机蒙脱土（OMMT）和藻酸盐用于疏水性药物负载和控制释放的载体。通过将蒙脱土钠（Na-MMT）与阳离子十六烷基三甲基溴化铵（CTAB），非离子壬基酚聚氧乙烯醚（NPE）以及它们的混合物通过简单便捷的湿式球磨法进行插层改性来合成OMMT。此外，通过在钙离子的外源交联下将藻酸盐用作包衣材料，构造了具有缓慢和受控释放性能的有机蒙脱土/藻酸盐（OMMT / Alg）复合水凝胶珠。通过扫描电子显微镜（SEM）对OMMT的物理和化学性质进行了比较评估，傅里叶变换红外光谱（FT-IR），X射线衍射（XRD），透射电子显微镜（TEM），动态光散射（DLS），热重分析仪（TGA），BET比表面积测量和药物吸附实验。实验结果表明，CTAB的存在能够通过阳离子交换反应促进CTAB / NPE嵌入Na-MMT。阳离子CTAB和非离子NPE通过湿式球磨过程被吸附或嵌入MMT层状结构中，可以改变Na-MMT的亲水性，提高其对疏水性药物分子的亲和力。此外，OMMT / Alg复合水凝胶珠粒比Na-MMT / Alg具有更好的缓释性能，主要归因于OMMT对疏水药物的良好亲和力，阻碍了药物的扩散。特别是，具有最高负载量（LC）和包封效率（EE）的CTA / NPE-MMT / Alg显示了疏水性布洛芬释放的最佳控制性能。释放遵循Korsmeyer-Peppas模型提出的非菲克扩散扩散机制。基于高载药量和出色的可控药物释放性能，将疏水性药物掺入亲水性基质的CTA / NPE-MMT / Alg可能是用于疏水性药物递送的极有前途的材料。释放遵循Korsmeyer-Peppas模型提出的非菲克扩散扩散机制。基于高载药量和出色的可控药物释放性能，将疏水性药物掺入亲水性基质的CTA / NPE-MMT / Alg可能是用于疏水性药物递送的极有前途的材料。释放遵循Korsmeyer-Peppas模型提出的非菲克扩散扩散机制。基于高载药量和出色的可控药物释放性能，将疏水性药物掺入亲水性基质的CTA / NPE-MMT / Alg可能是用于疏水性药物递送的极有前途的材料。