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Adverse childhood experiences and adult inflammation: single adversity, cumulative risk and latent class approaches
Brain, Behavior, and Immunity ( IF 8.8 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.bbi.2020.03.017
Rebecca E Lacey 1 , Snehal M Pinto Pereira 1 , Leah Li 2 , Andrea Danese 3
Affiliation  

Highlights • There is a reliance on ACE scores and single adversity approaches in ACEs research.• Latent class analysis (LCA) offers an alternative approach to operationalising ACEs.• We apply LCA to a large longitudinal study with prospective and retrospective ACEs data.• We compare LCA to ACE scores and individual ACE approaches in relations with inflammation.• Specific ACEs and ACE combinations are important for inflammation in mid-life.

中文翻译:

不良童年经历和成人炎症:单一逆境、累积风险和潜在类别方法

亮点 • 在 ACE 研究中依赖于 ACE 分数和单一逆境方法。• 潜在类别分析 (LCA) 提供了另一种操作 ACE 的方法。• 我们将 LCA 应用于具有前瞻性和回顾性 ACE 数据的大型纵向研究。• 我们将 LCA 与 ACE 评分和个体 ACE 方法与炎症的关系进行比较。• 特定的 ACE 和 ACE 组合对于中年炎症很重要。
更新日期:2020-07-01
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