Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.jmb.2020.03.018 Menglin Chen 1 , Kurt Fredrick 1
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In bacteria, the rates of transcription elongation and translation elongation are coordinated, changing together in response to growth conditions. It has been proposed that this is due to physical coupling of RNA polymerase and the lead ribosome on nascent mRNA, an interaction important for preventing premature transcription termination by Rho factor. Recent studies challenge this view and provide evidence that coordination is indirect, mediated in Escherichia coli by the alarmone (p)ppGpp. Here, we discuss these new findings and how they shape our understanding of the functional relationship between RNA polymerase and the ribosome as well as the basis of transcriptional polarity.
中文翻译：
RNA聚合酶与核糖体的关系：大多数时候不是那么物理。
在细菌中，转录伸长率和翻译伸长率是协调的，根据生长条件一起变化。已经提出这是由于RNA聚合酶和新生核糖体上的前核糖体的物理偶联，这种相互作用对于防止Rho因子过早终止转录很重要。最近的研究对这一观点提出了挑战，并提供证据表明，大黄酮（p）ppGpp在大肠杆菌中是间接的协调作用。在这里，我们讨论这些新发现，以及它们如何塑造我们对RNA聚合酶与核糖体之间的功能关系以及转录极性基础的理解。
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