Strategies to qualitatively and quantitatively enhance the humoral response to immunizations with protein and polysaccharide antigens are of broad interest for development of new and more effective vaccines. A strategy of increasing importance is the formulation of antigens into a particulate format, mimicking the physical form of viruses. The potential benefits of enhanced B cell receptor engagement by nanoparticles have been long been appreciated, but recent studies are defining additional important factors governing how nanoparticle immunogens interact with the immune system in the context of lymphoid organs. This review will discuss findings about how nanoparticles enhance humoral immunity in vivo and factors governing the fate of nanoparticle immunogens in lymph nodes.

中文翻译：

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通过抗原展示纳米粒子形成对疫苗的体液免疫。

定性和定量增强对蛋白质和多糖抗原免疫的体液反应的策略对于开发新的和更有效的疫苗具有广泛的兴趣。一个越来越重要的策略是将抗原制成微粒形式，模仿病毒的物理形式。纳米粒子增强 B 细胞受体参与的潜在好处长期以来一直受到重视，但最近的研究正在定义控制纳米粒子免疫原如何在淋巴器官背景下与免疫系统相互作用的其他重要因素。本综述将讨论关于纳米颗粒如何增强体内体液免疫的发现以及控制纳米颗粒免疫原在淋巴结中的命运的因素。