Abstract To bridge the gap between current in vitro and in vivo testing, we present the use of a perspiration simulator to evaluate the performance of skin adhesives during sweating. The perspiration simulator mimics human skin in key aspects such as roughness, water contact angle, sweat pore size, sweat pore density, and can be operated at different perspiration rates. In contrast to in vivo testing, a well-defined experimental setup with minimal variation is therefore successfully achieved. To demonstrate the capabilities of the reported perspiration simulator, two model adhesives with different water absorption capabilities are assessed. The peel forces as a function of time are thereby measured during perspiration of a 0.154 M NaCl solution. The peel force decreases immediately when the perspiration rate exceeds the water uptake as determined by an immersion test. However, when the water absorption capabilities are sufficiently high, a delay in the decrease in peel force is observed. Through the use of a fluorescent dye, we can further correlate the loss of adhesion with a spreading of liquid at the skin-adhesive interface.

中文翻译：

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排汗期间皮肤粘合剂的体外评估

摘要 为了弥补当前体外和体内测试之间的差距，我们提出了使用排汗模拟器来评估出汗过程中皮肤粘合剂的性能。排汗模拟器在粗糙度、水接触角、汗孔大小、汗孔密度等关键方面模拟人体皮肤，并且可以在不同的排汗率下运行。与体内测试相反，因此成功实现了具有最小变化的明确定义的实验设置。为了证明所报告的排汗模拟器的能力，评估了两种具有不同吸水能力的模型粘合剂。从而在 0.154 M NaCl 溶液出汗期间测量作为时间函数的剥离力。当出汗率超过浸渍试验确定的吸水量时，剥离力立即降低。然而，当吸水能力足够高时，观察到剥离力降低的延迟。通过使用荧光染料，我们可以进一步将粘附力的丧失与皮肤-粘合剂界面处的液体扩散联系起来。