Phosphorus is a common additive used in food processing that is typically consumed in excess of the recommended daily allowance; however, our knowledge of its effects on health, in the context of normal renal function, is limited. Unlike phosphorus, calcium intake is generally less than recommended, and it has been hypothesized that the calcium to phosphorus ratio may be partly responsible for the proposed negative health consequences. Therefore, this study sought to determine the effects of increased phosphorus additive intake, in the context of high calcium consumption, on endocrine markers of mineral metabolism and cardiometabolic health. An outpatient feeding study was performed in which healthy adults were fed a run-in control diet for 2 weeks followed by a phosphorus additive enhanced diet with supplemental calcium to an approximate ratio of 1 (experimental diet) for 2 weeks. Blood and urine samples were collected, and participants had brachial flow-mediated dilatation measured, with analyses comparing follow-up measures to baseline. Two weeks of experimental diet increased serum fibroblast growth factor 23 concentrations but lowered body weight and serum leptin; however, other phosphorus responsive factors such as osteopontin and osteocalcin did not increase. A complementary study in male mice also demonstrated that the regulation of known dietary phosphorus responsive factors was mostly abrogated when dietary calcium was raised in parallel with phosphorus. In conclusion, the study identifies weight, leptin and insulin as responsive to dietary phosphorus and that certain aspects of the systemic phosphorus response are attenuated by a corresponding high calcium intake.

磷是食品加工中常用的添加剂，其消耗量通常超过每日推荐摄入量；然而，在肾功能正常的情况下，我们对其对健康的影响的了解是有限的。与磷不同，钙的摄入量通常低于推荐量，据推测，钙与磷的比例可能是造成负面健康后果的部分原因。因此，本研究试图确定在高钙消耗的情况下增加磷添加剂摄入对矿物质代谢和心脏代谢健康的内分泌标志物的影响。进行了一项门诊喂养研究，其中健康成人被喂食磨合对照饮食 2 周，然后是磷添加剂增强饮食，补充钙的比例约为 1（实验饮食），持续 2 周。收集了血液和尿液样本，并对参与者进行了肱动脉血流介导的扩张测量，并进行了比较后续措施与基线的分析。两周的实验性饮食增加了血清成纤维细胞生长因子 23 的浓度，但降低了体重和血清瘦素；然而，其他磷反应因子如骨桥蛋白和骨钙素没有增加。一项针对雄性小鼠的补充研究还表明，当膳食钙与磷同时升高时，已知膳食磷反应因子的调节大部分被取消。综上所述，