Abstract Space charge effects and internal standardization were evaluated in quadrupole inductively coupled plasma mass spectrometry (ICP-MS). Changes in analyte ion sensitivities as a function of analyte ion mass (11B+, 24Mg+, 45Sc+, 60Ni+, 71Ga+, 75As+, 111Cd+, 138Ba+ and 172Yb+) due to the presence of seven different matrix elements (23Na+, 63Cu+, 89Y+, 115In+, 159Tb+, 175Lu+ and 205Tl+) were measured by a current ICP-MS instrument arrangement. Elements with different masses (light, middle and high mass range) were evaluated as internal standard (IS): 7Li+, 88Sr+ and 209Bi+. Space charge effects generally becomes more severe for matrices containing elements with middle mass (115In+) and high masses (159Tb+, 175Lu+ and 205Tl+) but are not dependent on the masses of most analyte ions, differently from which was known about space charge effects when using first generation ICP-MS instruments. Thus, a single IS was effective for minimize the matrix induced changes (range from −20 to +20%) for analytes with different masses in In matrix (except to mass-to-charge ratio lower than 50); Tb matrix (except to 7Li+); Lu matrix (except to 175Yb+); and Tl matrix (except to 25Mg+).

中文翻译：

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四离子透镜接口中的空间电荷效应和内部标准化：四极杆电感耦合等离子体质谱有什么变化？

摘要 在四极杆电感耦合等离子体质谱 (ICP-MS) 中评估了空间电荷效应和内部标准化。由于存在七种不同的基质元素 (635Yb+、172Yb+、11B+、24Mg+、45Sc+、60Ni+、71Ga+、75As+、111Cd+、138Ba+ 和 172Yb+)，分析物离子灵敏度的变化是分析物离子质量的函数、175Lu+ 和 205Tl+) 由当前的 ICP-MS 仪器装置测量。具有不同质量（轻、中和高质量范围）的元素被评估为内标 (IS)：7Li+、88Sr+ 和 209Bi+。对于包含中等质量 (115In+) 和高质量 (159Tb+、175Lu+ 和 205Tl+) 元素但不依赖于大多数分析物离子的质量的基质，空间电荷效应通常变得更加严重，与使用第一代 ICP-MS 仪器时已知的空间电荷效应不同。因此，对于 In 基质中不同质量的分析物（质荷比低于 50 除外），单个 IS 可有效减少基质引起的变化（范围从 -20 到 +20%）；Tb 矩阵（7Li+ 除外）；卢矩阵（除至175Yb+）；和 Tl 基质（25Mg+ 除外）。