In this study, hybrid nanoparticles composed of poly(methylmethacrylate-co-laurylmethacrylate) (PMMA-co-LMA) and poly(3-(trimethoxysilyl)propyl methacrylate) (PMS) obtained via seeded emulsion polymerisation were synthesised. A series of copolymers of LMA and MMA was obtained via emulsion polymerisation in the presence of β-cyclodextrin as a phase transport catalyst. The resulting spherical particles of approximately 50 nm were used as seeds for MPS polymerisation, resulting in spherical core-shell particles. These materials were evaluated as vehicles for limonene. Initially, it was observed that the extent of particle swelling by limonene was enhanced at the highest fractions of LMA. The same trend was obtained when the loading capacity and encapsulation efficiency were determined. Although when the core contained PLMA only, the particles exhibited the highest encapsulation capacity, these nanoparticles presented the poorest control on the release of limonene. The cytotoxicity evaluation of the core-shell nanoparticles revealed that they are slightly cytotoxic with cell viabilities higher than 70% at all the concentrations. Our results indicated that core-shell nanoparticles containing a core composed of P(MMA-co-LMA) and a siloxane shell were promising vehicles for nonpolar and volatile compounds, such as limonene, and they showed potential for applications in various fields, such as pest control, food and pharmaceutical industries.

在这项研究中，聚组成的混合纳米粒子（甲基丙烯酸甲酯-共合成了通过种子乳液聚合获得的甲基丙烯酸-月桂酯（PMMA-co-LMA）和聚甲基丙烯酸3-（三甲氧基甲硅烷基）丙酯（PMS）。在β-环糊精作为相转移催化剂的存在下，通过乳液聚合获得了一系列的LMA和MMA共聚物。将所得的约50nm的球形颗粒用作MPS聚合的种子，得到球形核-壳颗粒。这些材料被评估为柠檬烯的载体。最初，观察到柠檬烯的颗粒溶胀程度在LMA的最高部分增加。当确定装载容量和包封效率时，获得了相同的趋势。尽管当核心仅包含PLMA时，颗粒的包封能力最高，这些纳米颗粒对柠檬烯的释放控制最差。核-壳纳米颗粒的细胞毒性评估显示，它们具有轻微的细胞毒性，在所有浓度下细胞活力均高于70％。我们的结果表明，包含由P（MMA-co-LMA）组成的核和硅氧烷壳的核-壳纳米粒子是非极性和挥发性化合物（如柠檬烯）的有希望的载体，它们显示了在各个领域中的应用潜力，例如害虫防治，食品和制药工业。