Abstract Silver (Ag) has been regarded as a significant antioxidant widely used in biosystem. Nevertheless, the loading level of Ag nanospecies needs to be controlled to prevent their potential risk to human health. Herein, nanocomposite consisting of Ag and molybdenum disulfide (MoS2) has been readily synthesized via a template solvothermal method. Characterized by SEM, TEM and EDX, the Ag@MoS2 composite morphology including nanoflower, hollow sphere and solid sphere could be well controlled by adjusting solvent type and precursor-template ratio during the synthesis process. The composite structure of all three morphologies was further confirmed by XRD, Raman and N2 adsorption-desorption measurements. Ag@MoS2 nanoflower and hollow sphere, in which nanosized Ag was anchored (or encapsulated) within MoS2 nanosheets, obviously boosted the radical (1,1-diphenyl-2-picyrl, DPPH and nitride oxide, NO) scavenging efficiency (minimum IC50,DPPH = 26 μg/mL while IC50,NO = 46 μg/mL) with an Ag dosage much lowered to merely 7∼20 μg/mL. As a contrast, weaker activity of radical scavenging could be observed for Ag@MoS2 solid sphere. Our work will shed new lights on the cost-effective strategy to obtain a biosafe antioxidant.

中文翻译：

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在低银负载下具有改善的抗氧化活性的 Ag@MoS2 复合材料的形态可控制造

摘要 银（Ag）被认为是一种重要的抗氧化剂，广泛应用于生物系统。然而，需要控制纳米银的负载水平，以防止它们对人类健康的潜在风险。在此，由银和二硫化钼 (MoS2) 组成的纳米复合材料已通过模板溶剂热法很容易合成。通过 SEM、TEM 和 EDX 表征，通过在合成过程中调整溶剂类型和前体-模板比，可以很好地控制包括纳米花、空心球和实心球在内的 Ag@MoS2 复合形态。通过XRD、拉曼和N2 吸附-解吸测量进一步证实了所有三种形态的复合结构。Ag@MoS2 纳米花和空心球，其中纳米尺寸的 Ag 锚定（或封装）在 MoS2 纳米片内，明显促进了自由基（1，1-diphenyl-2-picyrl, DPPH 和氮氧化物, NO) 清除效率（最小 IC50,DPPH = 26 μg/mL 而 IC50,NO = 46 μg/mL），Ag 用量大大降低至仅 7∼20 μg/mL毫升。相比之下，Ag@MoS2 固体球体的自由基清除活性较弱。我们的工作将为获得生物安全抗氧化剂的成本效益策略提供新的思路。