Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.

中文翻译：

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一种有希望的防止氨引发癌症的CPS1抑制剂

氨基甲酸酯磷酸合成酶1（CPS1）驱动氨转化为氨基甲酸酯磷酸，其过表达支持嘧啶合成和肿瘤生长，从而突出了CPS1抑制作为治疗靶标的潜力。在本期《细胞化学生物学》中，姚等人。（2020）引入H3B-120作为有前途的新型CPS1抑制剂。