The first total synthesis of the pro-resolving lipid mediator 7(S),12(R),13(S)-Resolvin T2 [7(S),12(R),13(S)-RvT2] and its 13(R)-epimer, derived from n-3 docosapentaenoic acid (n-3 DPA), are described. 7(S),12(R),13(S)-RvT2 and its 13(R)-epimer were obtained by total synthesis using a chiral pool strategy to introduce the chiral centers. C7 was generated from S-(-)-1,2,4-butanetriol in both molecules and the C12 and C13 centers were generated from L-(+)-ribose and D-(-)-arabinose respectively. Cis and trans-selective Wittig reactions, selective deprotections, and Dess-Martin periodinane oxidation were the key steps in the syntheses.

亲分解脂质介体7（S），12（R），13（S）-Resolvin T2 [7（S），12（R），13（S）-RvT2]及其13（描述了衍生自n-3二十二碳五烯酸（n-3 DPA）的R 1-末端。使用手性池策略引入手性中心，通过全合成得到7（S），12（R），13（S）-RvT2及其13（R）-顶基。C7由两个分子中的S -（-）-1,2,4-丁三醇生成，C12和C13中心分别由L-（+）-核糖和D-（-）-阿拉伯糖生成。顺式和反式Wittig反应，选择性脱保护和Dess-Martin高碘烷氧化是合成的关键步骤。