The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP). This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n = 47) and non-MP group (n = 54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up. Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there was no significant difference in the proportion of Frankel grade (A-C) between the two groups at final follow-up. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group (P = 0.034). Management therapy with intraoperative 500 mg MP showed better recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF compared with those did not receive MP. However, long-term follow-up results showed that there was no significant difference in neurological recovery between patients with intraoperative MP or not. Moreover, intraoperative MP increased the rate of wound infection.

中文翻译：

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术中500 mg甲基强的松龙单次手术治疗黄韧带骨化引起的胸椎病的临床疗效

我们研究的目的是比较因使用和不使用术中甲基强的松龙（MP）治疗的黄韧带骨化症（OLF）骨化引起的胸椎病患者的临床结局和术后并发症。这项回顾性研究招募了101名接受后路入路手术的OLF患者，并至少随访了1年。根据手术中MP的使用情况将患者分为两组：MP组（n = 47）和非MP组（n = 54）。在手术前后和最后一次随访中评估临床结果和并发症。两组在手术后和随访2周后，日本骨科协会（mJOA）评分和Frankel评分（AC）比例之间存在显着差异。术前和最终随访时两组的mJOA评分无明显差异。此外，根据mJOA评分，在任何时间点的恢复率均无显着差异，在最终随访时两组之间的弗兰克尔等级（AC）比例也无显着差异。记录在案的感染有13种：MP组10例，非MP组3例（P = 0.034）。与未接受MP的患者相比，术中500 mg MP的管理疗法显示，由OLF引起的胸椎病患者在2周内神经功能恢复更好。但是，长期的随访结果表明，术中与否的患者之间神经功能恢复没有显着差异。此外，