The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however, this association is poorly understood in fibromyalgia. Our aim was to summarise the research reporting on the gastrointestinal microbiome and its biomarkers in people with fibromyalgia. A systematic review of published original research reporting on the gastrointestinal microbiota and its biomarkers in adults with a diagnosis of fibromyalgia was undertaken. From 4771 studies, 11 met our inclusion criteria and were separated into four main groups: papers reporting Helicobacter pylori; other gut bacterial markers; metabolomics and other biomarkers, which included intestinal permeability and small intestinal bacterial overgrowth. The results suggest there is a paucity of quality research in this area, with indications that the gut microbiota may play a role in fibromyalgia within the emerging field of the gut-musculoskeletal axis. Further investigations into the relationship between the gut microbiota, gut dysfunction and fibromyalgia are warranted.

中文翻译：

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确定纤维肌痛、肠道微生物组及其生物标志物之间的关联：系统评价


纤维肌痛和肠易激综合征之间的关联已明确。据报道，肠易激综合征中肠道微生物组的组成和多样性发生了变化，但对于纤维肌痛中的这种关联却知之甚少。我们的目的是总结有关纤维肌痛患者胃肠道微生物组及其生物标志物的研究报告。对已发表的关于诊断为纤维肌痛的成人胃肠道微生物群及其生物标志物的原始研究报告进行了系统回顾。在 4771 项研究中，有 11 项符合我们的纳入标准，并分为四个主要组：报告幽门螺杆菌的论文；其他肠道细菌标记物；代谢组学和其他生物标志物，包括肠道通透性和小肠细菌过度生长。结果表明，该领域缺乏高质量的研究，有迹象表明肠道微生物群可能在肠道-肌肉骨骼轴这一新兴领域的纤维肌痛中发挥作用。有必要进一步研究肠道微生物群、肠道功能障碍和纤维肌痛之间的关系。