The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Subjects in the senior cohort database of the Korean National Health Insurance Service (2002–2013) who completed the TUG as part of the National Screening Program for Transitional Ages (NSPTA) during 2007–2008 were identified. An abnormal TUG result was defined as a time ≥ 10 s. Cox proportional hazard models were used to assess the associations between TUG results and CV events, CV mortality, and all-cause mortality. The mean follow-up period was 5.7 years. Incidence rates of CV events in the normal and abnormal TUG groups were 7.93 and 8.98 per 1000 person-years, while CV mortality rates were 0.96 and 1.51 per 1000 person-years, respectively. In a fully adjusted model, we found that abnormal TUG results were not associated with the incidences of CV events and CV mortality. However, abnormal TUG results (≥10 s) resulted in a 2.9-fold increase in CV mortality in women (adjusted hazard ratio 2.90, 95% confidence interval 1.15–7.30). Further, participants lacking certain CV risk factors, such as current cigarette smoking, obesity, or diabetes, had a higher CV mortality rate when TUG results were abnormal. Abnormal TUG results in subjects aged 66 years were associated with future CV mortality in women and in subjects without obesity, diabetes, or cigarette smoking. In patient with mobility impairment, physicians should consider CV disease risk, especially in women.

中文翻译：

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定时测试结果与未来66岁成人心血管疾病发生率和死亡率的关联：韩国国家代表纵向研究，历时5.7年

定时测试（TUG）是最广泛使用的移动性测试之一。我们旨在检查TUG是否与心血管事件，心血管死亡率和全因死亡率相关。在韩国国民健康保险局（2002-2013）的高级队列数据库中，确定了在2007-2008年间完成了过渡时期国家筛查计划（NSPTA）一部分的TUG的受试者。TUG结果异常定义为时间≥10 s。使用Cox比例风险模型评估TUG结果与CV事件，CV死亡率和全因死亡率之间的关联。平均随访期为5。7年。正常和异常TUG组的CV事件发生率分别为每千人年7.93和8.98，而CV死亡率分别为每千人年0.96和1.51。在完全调整的模型中，我们发现异常的TUG结果与CV事件的发生率和CV死亡率无关。但是，异常的TUG结果（≥10 s）导致女性的CV死亡率增加了2.9倍（调整后的危险比2.90，95％置信区间1.15–7.30）。此外，当TUG结果异常时，缺乏某些CV危险因素（例如当前吸烟，肥胖或糖尿病）的参与者的CV死亡率较高。66岁受试者的TUG异常结果与女性以及没有肥胖，糖尿病或吸烟的受试者未来的CV死亡率有关。对于行动不便的患者，医生应考虑心血管疾病的风险，尤其是女性。但是，异常的TUG结果（≥10 s）导致女性的CV死亡率增加了2.9倍（调整后的危险比2.90，95％置信区间1.15–7.30）。此外，当TUG结果异常时，缺乏某些CV危险因素（例如当前吸烟，肥胖或糖尿病）的参与者的CV死亡率较高。66岁受试者的TUG异常结果与女性以及没有肥胖，糖尿病或吸烟的受试者未来的CV死亡率有关。对于行动不便的患者，医生应考虑心血管疾病的风险，尤其是女性。但是，异常的TUG结果（≥10 s）导致女性的CV死亡率增加了2.9倍（调整后的危险比2.90，95％置信区间1.15–7.30）。此外，当TUG结果异常时，缺乏某些CV危险因素（例如当前吸烟，肥胖或糖尿病）的参与者的CV死亡率较高。66岁受试者的TUG异常结果与女性以及没有肥胖，糖尿病或吸烟的受试者未来的CV死亡率有关。对于行动不便的患者，医生应考虑心血管疾病的风险，尤其是女性。TUG结果异常时，糖尿病或糖尿病的CV死亡率更高。66岁受试者的TUG异常结果与女性以及没有肥胖，糖尿病或吸烟的受试者未来的CV死亡率有关。对于行动不便的患者，医生应考虑心血管疾病的风险，尤其是女性。TUG结果异常时，糖尿病或糖尿病的CV死亡率更高。66岁受试者的TUG异常结果与女性以及没有肥胖，糖尿病或吸烟的受试者未来的CV死亡率有关。对于行动不便的患者，医生应考虑心血管疾病的风险，尤其是女性。