Although in many studies, the relationship between autoimmune hypothyroidism (Hashimoto) and Vitamin D deficiency was shown, no research has been performed on the role of vitamin D in non-autoimmune hypothyroidism. This was a case-control study in Endocrinology clinic of Jahrom (south of Iran). The patients with Hashimoto (n = 633) and non-Hashimoto hypothyroidism (n = 305), along with a control group (n = 200) were evaluated. 25(OH) D level, T3 and T4 levels were studied and Anti TPO and Anti TG tests were performed. The results of vitamin D level were analyzed and interpreted using SPSS in terms of the cause of hypothyroidism (immune and non-immune). The results of the study showed a significantly lower level of vitamin D in both immune and non-immune Hashimoto’s thyroiditis (HT) in comparison to healthy controls (P < 0.05). We observed a significant inverse correlation between the vitamin D and TGAb level (p = 0.001, r = − 0.261) and a direct correlation of vitamin D with TSH level (p = 0.008, r = 0.108) in Hashimoto thyroiditis patients. Finally, the results indicated that non-autoimmune hypothyroidism, as well as HT, is associated with vitamin D deficiency. The role of vitamin D deficiency in Hashimoto thyroiditis was thought to be in the association of higher autoantibody (TGAb) level; while, there should be further studies determining vitamin D deficiency’s role in non-immune hypothyroidism.

中文翻译：

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非自身免疫性甲状腺功能减退症维生素 D 缺乏：病例对照研究。


尽管许多研究表明自身免疫性甲状腺功能减退症（桥本）与维生素 D 缺乏之间的关系，但尚未研究维生素 D 在非自身免疫性甲状腺功能减退症中的作用。这是贾罗姆（伊朗南部）内分泌诊所的一项病例对照研究。对桥本甲状腺功能减退症患者 (n = 633) 和非桥本甲状腺功能减退症患者 (n = 305) 以及对照组 (n = 200) 进行了评估。研究了 25(OH)D 水平、T3 和 T4 水平，并进行了抗 TPO 和抗 TG 测试。使用SPSS对维生素D水平的结果进行分析，并根据甲状腺功能减退的原因（免疫性和非免疫性）进行解释。研究结果显示，与健康对照相比，免疫性和非免疫性桥本甲状腺炎 (HT) 患者的维生素 D 水平显着降低 (P < 0.05)。我们观察到桥本甲状腺炎患者维生素 D 和 TGAb 水平之间存在显着负相关（p = 0.001，r = − 0.261），而维生素 D 与 TSH 水平呈正相关（p = 0.008，r = 0.108）。最后，结果表明非自身免疫性甲状腺功能减退症以及 HT 与维生素 D 缺乏有关。维生素 D 缺乏在桥本甲状腺炎中的作用被认为与较高的自身抗体 (TGAb) 水平有关；同时，应该进一步研究确定维生素 D 缺乏在非免疫性甲状腺功能减退症中的作用。