Previous epidemiological evidence has identified many risk factors for coronary artery disease (CAD). Pulse pressure (PP) was reported to be associated with CAD. However, more attention was paid to aortic PP than to brachial PP. This cross-sectional study aimed to investigate the direct relationship between brachial PP and the presence and extent of CAD in stable angina patients. We recruited a total of 1118 consecutive patients with stable chest pain suspected of CAD. After screening with exclusion criteria, 654 patients were finally included in our study. Every patient underwent both blood pressure measurement and selective coronary angiography. Univariate and multivariate analysis were performed to analyze the association between PP and the presence and extent of CAD. This study revealed that brachial PP was an independent correlate of multivessel CAD. In multivariate generalized linear regression model, increasing brachial PP (per 1 mmHg) were associated with the increased number of diseased vessels (β = 0.01, SE = 0.00, P < 0.0001). Binary logistic regression analysis further confirmed this association. The risk of multivessel CAD increased significantly in patients with brachial PP ≥ 60 mmHg (OR = 1.69, 95% CI = 1.14–2.48, P = 0.0084) and as per 1 mmHg increased in brachial PP (OR = 1.02, 95% CI = 1.01–1.03, P = 0.0002), independent of age, gender, body mass index (BMI), smoking, diabetes, hypercholesterolemia and creatinine (Cr). This association was still of statistical significance in subgroup analysis of hypertension and diabetes. Increasing brachial PP was significantly and independently associated with increased risk of multivessel coronary disease in stable angina patients. The association of brachial PP with CAD was more pronounced in hypertension group than in non-hypertension one.

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稳定型心绞痛患者的肱脉压与冠状动脉疾病的存在和程度有关：一项横断面研究

先前的流行病学证据已经确定了许多冠状动脉疾病（CAD）的危险因素。据报道脉压（PP）与CAD相关。但是，与主动脉PP相比，对主动脉PP的关注更多。这项横断面研究旨在调查稳定型心绞痛患者肱PP与CAD的存在和程度之间的直接关系。我们共招募了1118名连续疑似CAD的稳定胸痛患者。经过排除标准筛选后，最终有654名患者被纳入我们的研究。每位患者都进行了血压测量和选择性冠状动脉造影。进行单因素和多因素分析以分析PP与CAD的存在和程度之间的关联。这项研究表明肱PP是多支血管CAD的独立关联。在多变量广义线性回归模型中，肱动脉PP增加（每1 mmHg）与患病血管数量增加相关（β= 0.01，SE = 0.00，P <0.0001）。二元逻辑回归分析进一步证实了这种关联。臂丛PP≥60 mmHg（OR = 1.69，95％CI = 1.14–2.48，P = 0.0084）的患者多血管CAD的风险显着增加，臂丛PP每升高1 mmHg（OR = 1.02，95％CI = 1.01-1.03，P = 0.0002），与年龄，性别，体重指数（BMI），吸烟，糖尿病，高胆固醇血症和肌酐（Cr）无关。这种关联在高血压和糖尿病的亚组分析中仍然具有统计学意义。稳定型心绞痛患者肱动脉PP的增加显着且独立地与多支冠状动脉疾病风险增加相关。与非高血压组相比，高血压组肱PP与CAD的关联更为明显。