当前位置：
X-MOL 学术
›
J. Nat. Prod.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Bulbimidazoles A-C, Antimicrobial and Cytotoxic Alkanoyl Imidazoles from a Marine Gammaproteobacterium Microbulbifer Species.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-03-19 , DOI: 10.1021/acs.jnatprod.0c00082 Md Rokon Ul Karim 1 , Enjuro Harunari 1 , Naoya Oku 1 , Kazuaki Akasaka 2 , Yasuhiro Igarashi 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-03-19 , DOI: 10.1021/acs.jnatprod.0c00082 Md Rokon Ul Karim 1 , Enjuro Harunari 1 , Naoya Oku 1 , Kazuaki Akasaka 2 , Yasuhiro Igarashi 1
Affiliation
|
Three new alkanoyl imidazoles, designated bulbimidazoles A-C (1-3), were found from the culture extract of the gammaproteobacterium Microbulbifer sp. DC3-6 isolated from a stony coral of the genus Tubastraea. The absolute configuration of the anteiso-methyl substitution in 1 was established to be a mixture of (R)- and (S)-configurations in a ratio of 9:91 by applying the Ohrui-Akasaka method. Compounds 1-3 displayed unique broad-spectrum antimicrobial activity against Gram-positive and -negative bacteria and fungi with MICs ranging from 0.78 to 12.5 μg/mL. They also exhibited cytotoxicity toward P388 murine leukemia cells with IC50 in the micromolar range.
中文翻译：
来自海洋γ-变形杆菌微球菌种的Bulbimidazoles AC，抗微生物和细胞毒性的烷酰基咪唑。
从γ-变形杆菌Microbulbifer sp。的培养物中发现了三种新的烷酰基咪唑，命名为bulbimidazoles AC（1-3）。DC3-6分离自杜巴属的石质珊瑚。通过应用Ohrui-Akasaka方法，将1中的前异甲基取代的绝对构型确定为（R）-和（S）-构型的比例为9:91的混合物。化合物1-3对革兰氏阳性和阴性细菌和真菌具有独特的广谱抗菌活性，MIC范围为0.78至12.5μg/ mL。他们还表现出对P388鼠白血病细胞的细胞毒性，IC50在微摩尔范围内。
更新日期：2020-03-19
中文翻译：
来自海洋γ-变形杆菌微球菌种的Bulbimidazoles AC，抗微生物和细胞毒性的烷酰基咪唑。
从γ-变形杆菌Microbulbifer sp。的培养物中发现了三种新的烷酰基咪唑，命名为bulbimidazoles AC（1-3）。DC3-6分离自杜巴属的石质珊瑚。通过应用Ohrui-Akasaka方法，将1中的前异甲基取代的绝对构型确定为（R）-和（S）-构型的比例为9:91的混合物。化合物1-3对革兰氏阳性和阴性细菌和真菌具有独特的广谱抗菌活性，MIC范围为0.78至12.5μg/ mL。他们还表现出对P388鼠白血病细胞的细胞毒性，IC50在微摩尔范围内。
京公网安备 11010802027423号