Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules,Macromolecules

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Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules
Macromolecules ( IF 5.1 ) Pub Date : 2020-03-19 , DOI: 10.1021/acs.macromol.9b02595
Ziwen Jiang ₁ , Hongxu Liu ₁ , Huan He ₁ , Alexander E. Ribbe ₂ , S. Thayumanavan ₁

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Self-assembly of amphiphilic polymers in aqueous solution builds up versatile carrier platforms for therapeutic delivery. Amphiphilic polymers specifically provide “hydrophobic pockets” for the encapsulation of water-insoluble small-molecule drugs, along with effective strategies to control the cargo release. Random and block copolymers have been separately demonstrated to affect the cargo encapsulation and release. In this study, we present self-assembled structures of blended random and block copolymers to tune the encapsulation and release of lipophilic cargo molecules. The hydrophilic–lipophilic balance (HLB) within the polymeric (co-)assemblies greatly affects their cargo loading capacity. Meanwhile, the disulfide moieties within the polymeric assemblies allow controlled cargo release upon a redox stimulus such as glutathione. The triggered release of encapsulated cargos is affected by the overall HLB, the reactivity, and accessibility of the disulfide species within the polymeric assemblies.

中文翻译：

两亲性无规和嵌段共聚物的可混组装，用于疏水性客体分子的可调节包封和释放

两性聚合物在水溶液中的自组装建立了用于治疗性递送的通用载体平台。两亲性聚合物特别为水不溶性小分子药物的封装提供“疏水口袋”，以及控制货物释放的有效策略。已经分别证明了无规和嵌段共聚物会影响货物的封装和释放。在这项研究中，我们提出了混合无规和嵌段共聚物的自组装结构，以调节亲脂性货物分子的包封和释放。聚合物（共）组件中的亲水亲脂平衡（HLB）极大地影响了它们的载货能力。同时，聚合物组件中的二硫键部分允许在氧化还原刺激物如谷胱甘肽作用下控制货物的释放。

更新日期：2020-04-24

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