Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis.,ACS Nano

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Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis.
ACS Nano ( IF 15.8 ) Pub Date : 2020-03-19 , DOI: 10.1021/acsnano.0c00007
Young-Hyeon An ₁ , Joon Lee _{2,

3} , Dong Uk Son ₃ , Dong Hyeon Kang ₂ , Mihn Jeong Park ₂ , Kyoung Won Cho _{2,

4} , Semin Kim ₅ , Su-Hwan Kim ₂ , Junghyeon Ko ₁ , Myoung-Hoon Jang ₃ , Jae Young Lee ₅ , Dae-Hyeong Kim _{1,

2,

4} , Nathaniel S Hwang _{1,

2}

Affiliation

We herein developed an iontophoretic transdermal drug delivery system for the effective delivery of electrically mobile drug nanocarriers (DNs). Our system consists of a portable and disposable reverse electrodialysis (RED) battery that generates electric power for iontophoresis through the ionic exchange. In addition, in order to provide a drug reservoir to the RED-driven iontophoretic system, an electroconductive hydrogel composed of polypyrrole-incorporated poly(vinyl alcohol) (PYP) was used. The PYP hydrogel facilitated electron transfer from the RED battery and accelerated the mobility of electrically mobile DNs released from the PYP hydrogel. In this study, we showed that fluconazole- or rosiglitazone-loaded DNs could be functionalized with charge-inducing agents, and DNs with charge modification resulted in facilitated transdermal transport via repulsive RED-driven iontophoresis. In addition, topical application and RED-driven iontophoresis of rosiglitazone-loaded DNs resulted in an effective antiobese condition displaying decreased bodyweight, reduced glucose level, and increased conversion of white adipose tissues to brown adipose tissues in vivo. Consequently, we highlight that this transdermal drug delivery platform would be extensively utilized for delivering diverse therapeutic agents in a noninvasive way.

中文翻译：

使用纳米载体-嵌入的导电水凝胶结合反向电渗析驱动的离子电渗疗法，促进透皮药物递送。

我们在本文中开发了一种离子电渗透皮药物递送系统，用于有效递送电动药物纳米载体（DNs）。我们的系统由便携式和一次性的反向电渗析（RED）电池组成，该电池通过离子交换产生用于离子电渗疗法的电能。另外，为了向RED驱动的离子电渗疗法系统提供药物储库，使用了由掺有聚吡咯的聚乙烯醇（PYP）构成的导电水凝胶。PYP水凝胶促进了从RED电池的电子转移，并加速了从PYP水凝胶释放的电动DN的迁移。在这项研究中，我们表明，可以通过电荷诱导剂对氟康唑或罗格列酮装载的DN进行功能化，和带有电荷修饰的DNs通过排斥的RED驱动离子电渗疗法促进了透皮运输。此外，局部应用和罗格列酮DNs的RED驱动离子电渗疗法导致有效的抗肥胖病症状，表现为体重减轻，葡萄糖水平降低以及体内白色脂肪组织向棕色脂肪组织的转化增加。因此，我们着重指出，该透皮给药平台将被广泛用于以无创方式提供多种治疗药物。体内白色脂肪组织向棕色脂肪组织的转化增加。因此，我们着重指出，该透皮给药平台将被广泛用于以无创方式提供多种治疗药物。体内白色脂肪组织向棕色脂肪组织的转化增加。因此，我们着重指出，该透皮给药平台将被广泛用于以无创方式提供多种治疗药物。

更新日期：2020-03-19

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