Long noncoding RNAs (lncRNA) play important roles in maintaining morphology and function of tissues, and their regulatory effectiveness is closely associated with spatial expression. To provide a comprehensive spatial atlas of expression for lncRNA, we propose LncSpA (http://bio-bigdata.hrbmu.edu.cn/LncSpA) to explore tissue-elevated (TE) lncRNA across human normal and adult and pediatric cancer tissues. In total, 71,131 and 12,007 TE lncRNAs and 634 clinical-related TE lncRNAs were identified across 38 normal and 33 adult cancer tissues. Moreover, 4,688 TE and 413 clinical-related lncRNAs were identified in pediatric cancer. By quick searching or query options, users can obtain eight major types of detailed information for lncRNA via various visualization techniques, including qualitative and quantitative spatial expression in different resources, coexpressed mRNAs, predicted function, known disease association, and the potential to serve as diagnostic or prognostic markers. LncSpA will be a valuable resource to understand lncRNA functions across tissues and cancers, leading to enhanced therapeutic strategies in precision oncology. SIGNIFICANCE: LncSpA is a new interactive resource that provides the spatial expression pattern of lncRNA across thousands of normal and cancer samples representing major tissue types.

中文翻译：

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LncSpA：横跨正常组织和癌症组织的LncRNA空间表达图谱。

长非编码RNA（lncRNA）在维持组织的形态和功能中起重要作用，并且其调控效果与空间表达密切相关。为了提供lncRNA表达的全面空间图谱，我们提出了LncSpA（http://bio-bigdata.hrbmu.edu.cn/LncSpA），以研究人类正常，成人和儿科癌症组织中的组织升高（TE）lncRNA。总共在38个正常和33个成人癌症组织中鉴定出71,131和12,007个TE lncRNA，以及634个与临床相关的TE lncRNA。此外，在儿科癌症中鉴定出4688个TE和413个临床相关的lncRNA。通过快速搜索或查询选项，用户可以通过各种可视化技术获得lncRNA的八种主要类型的详细信息，包括不同资源中的定性和定量空间表达，共表达的mRNA，预测的功能，已知的疾病关联以及用作诊断或预后标志物的潜力。LncSpA将是了解跨组织和癌症的lncRNA功能的宝贵资源，从而可以提高精确肿瘤学的治疗策略。意义：LncSpA是一种新的交互式资源，可在代表主要组织类型的数千个正常和癌症样本中提供lncRNA的空间表达模式。