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Synthesis of cis β‐Hydroxy Ketones by Desymmetrization of 1,3‐Cyclopentanediones through Ruthenium‐Catalyzed Hydrogen Transfer
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-31 , DOI: 10.1002/ajoc.202000121
Han Wang 1 , Yang Zhao 2 , Yi‐Xuan Ding 2 , Chang‐Bin Yu 2 , Yong‐Gui Zhou 1, 2
Affiliation  

A facile synthesis of chiral cis β‐hydroxy ketones was successfully developed through ruthenium‐catalyzed transfer hydrogenative desymmetrization of 1,3‐cyclopentanedione. The experiment on gram scale could be performed without loss of reactivity and enantioselectivity.

中文翻译:

1,3-环戊二酮的不对称化通过钌催化的氢转移合成顺式β-羟基酮

通过钌催化的1,3-环戊二酮的氢化转移不对称化,成功开发了一种手性顺式β-羟基酮的简便合成方法。可以进行克级实验,而不会损失反应性和对映选择性。
更新日期:2020-03-31
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