Novel piperazine-tailored ursolic acid hybrids as significant antibacterial agents targeting phytopathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri probably directed by activation of apoptosis.,Pest Management Science

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Novel piperazine-tailored ursolic acid hybrids as significant antibacterial agents targeting phytopathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri probably directed by activation of apoptosis.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-03-18 , DOI: 10.1002/ps.5822
Pei-Yi Wang ₁ , Meng Xiang ₁ , Min Luo ₁ , Hong-Wu Liu ₁ , Xiang Zhou ₁ , Zhi-Bing Wu ₁ , Li-Wei Liu ₁ , Zhong Li ₂ , Song Yang _{1,

2}

Affiliation

Induced apoptosis is an effective technique that can reprogram cellular physiological and pathological processes to eradicate undesirable cells using their innate systems. Inspired by this, numerous apoptosis inducers have been developed to treat animal diseases, especially in the anticancer field. However, few studies have reported on the development of inductive agents that attack plant pathogens by activation of apoptosis. With the aim of exploring and discovering apoptosis inducers that target phytopathogens, a cluster of piperazine‐tailored ursolic acid (UA) hybrids was systematically fabricated.

中文翻译：

新型哌嗪定制熊果酸杂种作为针对植物病原体米黄单胞菌的重要抗菌剂。 oryzae 和 X. axonopodis pv. citri 可能是通过细胞凋亡的激活来指导的。

诱导细胞凋亡是一种有效的技术，可以重新编程细胞的生理和病理过程，利用其先天系统根除不需要的细胞。受此启发，许多细胞凋亡诱导剂被开发出来用于治疗动物疾病，特别是在抗癌领域。然而，很少有研究报道通过激活细胞凋亡来攻击植物病原体的诱导剂的开发。为了探索和发现针对植物病原体的细胞凋亡诱导剂，系统地制备了一系列哌嗪定制的熊果酸（UA）杂种。

更新日期：2020-03-18

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