Methods and Approaches for the Solid-Phase Synthesis of Peptide Alcohols.,ChemPlusChem

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Methods and Approaches for the Solid-Phase Synthesis of Peptide Alcohols.
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-04-01 , DOI: 10.1002/cplu.201900749
Fernando J Ferrer-Gago ₁ , Li Quan Koh ₁

Affiliation

Many methods have been developed for attaching an alcohol functionality to a solid support. However, not all of these methods are used to obtain peptide alcohols. In this Minireview, we will discuss several of the most important methods and approaches for the synthesis of peptide alcohols and the attachment of hydroxy groups to a solid support for the synthesis of cyclic peptides. Some of the methods include the use of functionalized Wang resin and the attachment of an alcohol to an enol ether resin. We also discuss the use of the chlorotrityl resin, one of the most common linkers used to obtain peptide alcohols. In addition, we outline the recently developed resins with the Rink, Ramage and Sieber handles. The majority of these methods have been used to synthesize many important drugs, such as octreotide and the antibiotic peptaibols.

中文翻译：

肽醇固相合成的方法和方法。

已经开发出许多方法来将醇官能团连接到固体载体上。然而，并非所有这些方法都用于获得肽醇。在此Minireview中，我们将讨论几种最重要的肽醇合成方法和方法，以及将羟基连接到环状肽合成的固体支持物上。一些方法包括使用官能化的Wang树脂以及将醇连接至烯醇醚树脂。我们还讨论了氯三苯甲基树脂的使用，这是用于获得肽醇的最常见的连接基之一。此外，我们还概述了最近开发的带有Rink，Ramage和Sieber手柄的树脂。这些方法中的大多数已用于合成许多重要的药物，例如奥曲肽和抗生素肽。

更新日期：2020-04-22

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