In article number 1901805 by Xiaojuan Xu and co‐workers, a targeted oral delivery system is constructed by loading methotrexate (MTX) into yeast glucan particles (YGPs) for inflammatory bowel disease therapy, which can be internalized into macrophages efficiently. Furthermore, YGPs accumulate in the inflammation site of colitis mice, enabling YGPs/MTX to target the inflammatory site, significantly improve the efficacy of MTX, and reduce the cytotoxicity of MTX.

中文翻译：

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神经再生：一种靶向通过葡聚糖颗粒递送甲氨蝶呤治疗炎症性肠病的新策略（Adv。Healthcare Mater。6/2020）

在徐小娟及其同事的第1901805号文章中，通过将甲氨蝶呤（MTX）装入酵母葡聚糖颗粒（YGPs）中用于炎症性肠病治疗，从而可以有效地内化成巨噬细胞，从而构建了靶向口服递送系统。此外，YGPs在结肠炎小鼠的炎症部位积聚，使YGPs / MTX能够靶向炎症部位，显着提高MTX的疗效，并降低MTX的细胞毒性。