Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice.,Food Science & Nutrition

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Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-03-18 , DOI: 10.1002/fsn3.1445
Keke Lu ₁ , Jing Wang ₁ , Yueyuan Yu ₂ , Yikuan Wu ₂ , Zhao He _{1,

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Affiliation

Oxidative stress and inflammation contribute to hypertriglyceridemia‐induced nonalcoholic fatty liver disease (NAFLD). Cholesterol‐enriched diets increase the risk of NAFLD. Lycium ruthenium Murr. (LRM) contains water‐soluble antioxidant proanthocyanidins. Whether Lycium ruthenium Murr. improves NAFLD remains elusive. In this study, we established a model of NAFLD‐induced by cholesterol‐enriched high‐fat diet (western diet) in ApoE^−/− mice; oxidative stress and inflammation were examined and intervened by supplement of Lycium ruthenium Murr. (LRM) extracts. LRM supplement did not influence body weight gain, food intake, and lipotoxicity of mice. LRM supplement significantly alleviated triglyceride accumulation in liver, with reduced inflammation, elevated GSH‐Px activity, and reduced MDA levels. The expression of fatty acids oxidative gene Scd1 was significantly increased, and fatty acids synthesis‐related gene Pparγ was dramatically downregulated on mRNA level in liver of mice with LRM supplement. These data demonstrated that LRM supplement decreased ROS production and inflammation, increased fatty acids oxidation, and reduced fatty acids synthesis in liver, leading to ameliorate the development of NAFLD induced by high western diet. Thus, oxidative stress and inflammation also are involved in the pathogenesis of western diet‐induced NAFLD, which is independent of obesity.

中文翻译：

黑果枸杞 Murr.减轻小鼠非酒精性脂肪肝。

氧化应激和炎症会导致高甘油三酯血症诱发的非酒精性脂肪肝（NAFLD）。富含胆固醇的饮食会增加 NAFLD 的风险。钌枸杞Murr. (LRM) 含有水溶性抗氧化剂原花青素。是否为枸杞钌穆尔。改善 NAFLD 仍然难以捉摸。在本研究中，我们在ApoE ^−/−小鼠中建立了富含胆固醇的高脂饮食（西方饮食）诱导的 NAFLD 模型；通过补充黑钌枸杞来检查和干预氧化应激和炎症。（LRM）提取物。 LRM补充剂不影响小鼠的体重增加、食物摄入和脂毒性。 LRM 补充剂显着减轻了肝脏中甘油三酯的积累，减少了炎症，提高了 GSH-Px 活性，并降低了 MDA 水平。补充 LRM 的小鼠肝脏中脂肪酸氧化基因Scd1的表达显着增加，脂肪酸合成相关基因Pparγ 的mRNA 水平显着下调。这些数据表明，LRM补充剂减少了ROS的产生和炎症，增加了脂肪酸氧化，并减少了肝脏中的脂肪酸合成，从而改善了高西方饮食诱导的NAFLD的发展。因此，氧化应激和炎症也参与了西方饮食诱发的 NAFLD 的发病机制，且与肥胖无关。

更新日期：2020-03-18

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