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Urine metallomics signature as an indicator of pancreatic cancer.
Metallomics ( IF 2.9 ) Pub Date : 2020-03-18 , DOI: 10.1039/d0mt00061b
Kathrin Schilling 1 , Fiona Larner , Amina Saad , Rhiannon Roberts , Hemant M Kocher , Oleg Blyuss , Alex N Halliday , Tatjana Crnogorac-Jurcevic
Affiliation  

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer. Its high mortality rate is attributed largely to the difficulty of early diagnosis. Analysis of urine is an excellent non-invasive approach to trace changes in biochemical reactions due to cancer development. Here we show remarkable differences in concentration of several essential metals: significantly lower levels of urinary calcium and magnesium and increased levels of copper and zinc in PDAC when compared to healthy controls, and demonstrate that a combined analysis of these essential metals are accurate indicators (sensitivity = 99.5%) for metal dyshomeostasis in PDAC. In addition, natural stable zinc isotope composition (δ66/64Zn) in urine reveals the preferential excretion of isotopically light zinc in PDAC (δ66/64Znmedian = −0.15‰) compared to healthy controls (δ66/64Znmedian = +0.02‰), likely supporting the dysregulation of metalloproteins. These findings demonstrate for the first time that metallomics is a promising approach for discovery of biomarkers for detection of patients with PDAC, completely non-invasively, using urine samples.

中文翻译:

尿金属学特征可作为胰腺癌的指标。

胰腺导管腺癌(PDAC)是最致命的癌症之一。其高死亡率主要归因于早期诊断的困难。尿液分析是一种出色的非侵入性方法,可以追踪由于癌症发展而引起的生化反应的变化。在这里,我们显示了几种必需金属浓度的显着差异:与健康对照相比,PDAC中尿钙和镁的含量明显降低,而铜和锌的含量显着增加,并且表明对这些必需金属的综合分析是准确的指标(敏感性= 99.5%)的PDAC中金属异位症。此外,天然稳定锌同位素组合物(δ 66/64尿Zn)的揭示同位素光锌在PDAC优先排泄(δ 66/64中位数= -0.15‰)相比健康对照(δ 66/64中位数= + 0.02‰),可能支持金属蛋白的失调。这些发现首次证明,金属学是一种有前途的发现生物标志物的有前途的方法,可以使用尿液样本以完全无创的方式检测PDAC患者。
更新日期:2020-03-18
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