A suspended graphene-based optical interferometric surface stress sensor for selective biomolecular detection,Nanoscale Advances

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A suspended graphene-based optical interferometric surface stress sensor for selective biomolecular detection
Nanoscale Advances ( IF 4.6 ) Pub Date : 2020-03-19 , DOI: 10.1039/c9na00788a
Shin Kidane ₁ , Hayato Ishida ₁ , Kazuaki Sawada ₁ , Kazuhiro Takahashi ₁

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Graphene-based sensors are of great interest in research due to their high specific surface area and high electron mobility that make them suitable for numerous advanced applications. In this paper, selective molecular detection using an antigen–antibody reaction on suspended graphene with a cavity-sealing structure was demonstrated. The suspended graphene sealed nanocavities in a pre-patterned Si substrate, which increased robustness and allowed the use of wet chemical processes for surface functionalization of the suspended graphene to achieve selective molecular binding. The selectivity was evaluated by nanomechanical deflection induced by molecular adsorption on the suspended graphene, resulting in spectral shifts in the optical interference between the suspended graphene and Si substrate. The chemically functionalized suspended graphene enables the analysis of intermolecular interactions and molecular kinetics by colorimetry using optical interference.

中文翻译：

用于选择性生物分子检测的悬浮石墨烯光学干涉表面应力传感器

基于石墨烯的传感器因其高比表面积和高电子迁移率而受到研究的极大兴趣，这使得它们适合许多先进的应用。在本文中，展示了利用抗原抗体反应对具有空腔密封结构的悬浮石墨烯进行选择性分子检测。悬浮石墨烯将纳米腔密封在预先图案化的硅基板中，这提高了鲁棒性，并允许使用湿化学工艺对悬浮石墨烯进行表面功能化，以实现选择性分子结合。通过悬浮石墨烯上的分子吸附引起的纳米机械偏转来评估选择性，导致悬浮石墨烯和硅基板之间的光学干涉光谱偏移。化学功能化的悬浮石墨烯能够利用光学干涉通过比色法分析分子间相互作用和分子动力学。

更新日期：2020-04-24

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