Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions,Nanoscale

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Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/18 , DOI: 10.1039/c9nr10588c
Jorge Leganés _{1,

2,

3,

4,

5} , Ana Sánchez-Migallón _{1,

2,

3,

4,

5} , Sonia Merino _{1,

2,

3,

4,

5} , Ester Vázquez _{1,

2,

3,

4,

5}

Affiliation

The study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic regions that allowed efficient loading of a series of drugs of increasing hydrophobicity (Metronidazole, Benzocaine, Ibuprofen, Naproxen and Imipramine), while simultaneously endowing swelling-induced pH-responsiveness to the hydrogel. Additionally, the incorporation of graphene was found to interfere with these hydrophobic domains through favourable non-covalent interactions, thus leading to the partial disruption of these aggregates. As a consequence, graphene facilitated and enhanced the release of model hydrophobic drug Imipramine in a synergistic manner with the pH trigger, and increased the swelling capacities and improved mechanical performance. This hybrid hydrogel can therefore be envisaged as a proof-of-concept system for the release of hydrophobic compounds in the field of drug delivery.

中文翻译：

三嗪疏水相互作用破坏驱动的基于刺激的基于石墨烯的水凝胶

此处报道的研究涉及用于药物输送领域的新型石墨烯-二氨基三嗪（G-DAT）纳米复合水凝胶的制备。这种材料的混合性质基于两个关键要素：DAT骨架的存在诱导了疏水区域的形成，从而可以有效负载一系列增加疏水性的药物（甲硝唑，苄卡因，布洛芬，萘普生和丙米嗪），而同时赋予水凝胶溶胀诱导的pH响应性。另外，发现石墨烯的掺入通过有利的非共价相互作用来干扰这些疏水域，从而导致这些聚集体的部分破坏。作为结果，石墨烯与pH引发剂协同作用，促进并增强了模型疏水性药物丙咪嗪的释放，并增加了溶胀能力并改善了机械性能。因此，可以将这种杂化水凝胶设想为在药物递送领域中用于释放疏水性化合物的概念验证系统。

更新日期：2020-04-03

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