Fifteen to thirty percentage of patients with severe aortic stenosis (AS) have preserved left ventricular ejection fraction (LVEF) and a discordant AS pattern at Doppler echocardiography, which is characterized by a small (<1 cm²) aortic area and low mean aortic gradient (<40 mmHg). The ‘Randomized study for the Optimal Treatment of symptomatic patients with low-gradient severe Aortic Stenosis and preserved left ventricular ejection fraction’ (ROTAS trial) aims at demonstrating the superiority of aortic valve replacement vs. a ‘watchful waiting strategy’ in symptomatic patients with low-gradient (LS), severe AS, and preserved LVEF, stratified according to indexed stroke volume, in terms of all-cause mortality or cardiovascular-related hospitalization during follow-up (FU).

中文翻译：

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ROTAS 研究的合理性和设计：一项针对低梯度重度主动脉瓣狭窄和保留左心室射血分数的有症状患者的最佳治疗的随机研究

15% 至 30% 的重度主动脉瓣狭窄 (AS) 患者的左心室射血分数 (LVEF) 保留，多普勒超声心动图显示不一致的 AS 模式，其特点是主动脉面积小 (<1 cm ² ) 和平均主动脉梯度低（<40 毫米汞柱）。“对低梯度重度主动脉瓣狭窄和保留左心室射血分数的症状患者进行优化治疗的随机研究”（ROTAS 试验）旨在证明主动脉瓣置换术与“观察等待策略”在有症状的有症状患者中的优越性。低梯度 (LS)、严重 AS 和保留的 LVEF，根据指数每搏输出量，在全因死亡率或随访期间心血管相关住院 (FU) 方面进行分层。