Group A streptococci (GAS) have previously accounted for a large portion of invasive neonatal infections, but differences in the access to medical care and in the antibiotic used over the last half century has significantly reduced such cases. A literature review reveals 17 neonatal GAS meningitis reports with positive CSF cultures since 1967, characterized by high morbidity and mortality. We present a case of a 10-day old well-appearing neonate diagnosed with GAS meningitis, exhibiting an excellent response to antimicrobial therapy. Epidemiological investigation revealed her mother as the likely source of postnatal transmission of GAS with an emm1.0 subtype. GAS meningitis is a rare cause of neonatal meningitis associated with high morbidity and mortality warranting further research assessing potential risk factors, modes of transmission, and therapeutic protocols.

中文翻译：

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新生儿A型链球菌脑膜炎。病例报告及文献复习

以前，A组链球菌（GAS）占了侵袭性新生儿感染的很大一部分，但是在过去的半个世纪中，获得医疗服务和使用的抗生素的差异大大减少了此类病例。文献综述显示，自1967年以来，有17例新生儿GAS脑膜炎的脑脊液培养阳性，其特点是发病率和死亡率高。我们介绍了一个诊断为GAS脑膜炎的10天大的外貌良好的新生儿，对抗菌治疗表现出出色的反应。流行病学调查显示，她的母亲可能是GAS产后经Emm传播的可能来源1.0子类型。GAS脑膜炎是与高发病率和高死亡率相关的新生儿脑膜炎的罕见病因，因此有必要进行进一步的研究以评估潜在的危险因素，传播方式和治疗方案。