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Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression.
Science Translational Medicine ( IF 15.8 ) Pub Date : 2020-03-18 , DOI: 10.1126/scitranslmed.aat6263
Fernando Real 1, 2, 3 , Claude Capron 4 , Alexis Sennepin 1, 2, 3 , Riccardo Arrigucci 5 , Aiwei Zhu 1, 2, 3 , Gérémy Sannier 1, 2, 3 , Jonathan Zheng 1, 2, 3 , Lin Xu 1, 2, 3 , Jean-Marc Massé 2, 3, 6 , Ségolène Greffe 7 , Michelle Cazabat 8 , Maribel Donoso 9 , Pierre Delobel 10, 11, 12 , Jacques Izopet 8, 10, 11 , Eliseo Eugenin 9 , Maria Laura Gennaro 5 , Elisabeth Rouveix 7 , Elisabeth Cramer Bordé 1, 2, 4 , Morgane Bomsel 1, 2, 3
Affiliation  

In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4+ T cell counts (<350 cells/μl) contained replication-competent HIV despite viral suppression. In vitro, human platelets harboring HIV propagated the virus to macrophages, a process that could be prevented with the biologic abciximab, an anti–integrin αIIb/β3 Fab. Furthermore, in our cohort, 88% of HIV-infected individuals on ART with viral suppression and with platelets containing HIV were poor immunological responders with CD4+ T cell counts remaining below <350 cells/μl for more than one year. Our study suggests that platelets may be transient carriers of HIV and may provide an alternative pathway for HIV dissemination in HIV-infected individuals on ART with viral suppression and poor CD4+ T cell recovery.



中文翻译:

尽管抗病毒药物被抑制,但是接受抗逆转录病毒药物治疗且CD4 + T细胞回收率较差的HIV感染者的血小板仍可以携带具有复制能力的HIV。

除止血外,人体血小板还具有多种免疫功能,并在体外与包括HIV在内的传染性病原体相互作用。在这里,我们报告说,尽管血液中的病毒被抑制,但血液中CD4 + T细胞计数低(<350细胞/μl)的联合抗逆转录病毒药物治疗(ART)的HIV感染者的血小板中仍含有能复制的HIV。在体外,携带HIV的人类血小板将病毒传播到巨噬细胞,而生物学上的阿昔单抗(一种抗整合素αIIb/β3Fab)可以阻止这一过程。此外,在我们的队列中,接受病毒抑制和含HIV血小板的抗病毒治疗的HIV感染者中有88%是CD4 +T细胞计数保持低于<350细胞/μl一年以上。我们的研究表明,血小板可能是HIV的短暂携带者,并可能为HIV感染个体中HIV抑制和CD4 + T细胞恢复不良提供HIV传播的替代途径。

更新日期:2020-03-19
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