Varicella zoster virus, the worldwide infectious human virus responsible for acute varicella and chickenpox, commonly spreads from exposure through contact with a skin lesion or airborne respiratory droplets. Keratinocytes, major targets and source of transmission of the virus present in the skin, represent an ideal choice of cell to stop early virus progression. In their recent study, Tommasi et al. show regulatory mechanisms of cytokeratin 10 through the protease kallikrein-6 as a suitable and druggable pathway to reduce varicella zoster virus dissemination.

中文翻译：

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Kallikrein-6调控的途径为水痘带状疱疹病毒感染的新潜在靶标提供了照明

水痘带状疱疹病毒是引起急性水痘和水痘的全球传染性人类病毒，通常通过接触皮肤病灶或空气传播的呼吸道飞沫而从暴露中传播。角质形成细胞是皮肤中病毒的主要靶标和传播源，是阻止早期病毒进展的理想细胞选择。在他们最近的研究中，Tommasi等人。显示出通过蛋白酶激肽释放酶-6的细胞角蛋白10的调节机制，作为减少水痘带状疱疹病毒传播的合适且可药物化的途径。