Wenzina et al. (2020) explore the potential role of E-cadherin (CDH1) as a marker for invasive behavior in melanoma. The authors show that CDH1 expression is modulated by p38 signaling, and that manipulation of this pathway can impede endothelial disruption and lung dissemination in vivo and in vitro. The downstream markers PODXL and DEL of the invasive phenotype are associated with a poor prognosis.

中文翻译：

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皮肤黑色素瘤的细胞表型可塑性：一个复杂的难题。

Wenzina等。（2020年）探讨了E-钙粘蛋白（CDH1）作为黑色素瘤侵袭行为标记的潜在作用。作者表明，CDH1表达受p38信号传导调节，对该途径的操纵可在体内和体外阻碍内皮破坏和肺扩散。侵袭性表型的下游标记PODXL和DEL与不良预后相关。