Curcumin has been extensively used in the food and pharmaceutical industries due to its high biological activity. However, its instability and poor aqueous solubility result in low oral bioavailability, so developing an appropriate microcapsule wall material is crucial for the effective use of this ingredient. In this study, a curcumin-loaded konjac glucomannan octenyl succinate (CKGOS) nanoemulsion with a high loading capacity (1.25 ± 0.03 mg/mL) was prepared. Fourier transform infrared spectroscopy and X-ray diffraction suggested that curcumin was successfully encapsulated into the nanoparticles. The observed self-aggregating morphology indicated that CKGOS particles were spherical with a rough matte edge morphology. Both in vitro and in vivo stability tests indicated that KGOS could provide good protection for curcumin and furnish colon-targeted delivery. In addition, CKGOS has great potential in food processing applications because it shows good thermal processing and storage stability.

姜黄素由于具有很高的生物活性而被广泛用于食品和制药行业。但是，其不稳定性和水溶性差导致口服生物利用度低，因此开发合适的微胶囊壁材料对于有效使用该成分至关重要。在这项研究中，制备了具有高负载量（1.25±0.03 mg / mL）的姜黄素负载的魔芋葡甘露聚糖辛烯基琥珀酸酯（CKGOS）纳米乳液。傅里叶变换红外光谱和X射线衍射表明姜黄素已成功地封装在纳米颗粒中。观察到的自聚集形态表明CKGOS颗粒是球形的，具有粗糙的无光泽边缘形态。二者在体外和体内稳定性测试表明，KGOS可以为姜黄素提供良好的保护，并提供结肠靶向性递送。另外，由于CKGOS具有良好的热加工和储存稳定性，因此在食品加工应用中具有巨大的潜力。