For the treatment of neurological disorders, polyphenols in Vaccinium berry species may be an effective addition to standard medicinal products. Polyphenols may reduce oxidative stress and inflammation, processes believed to contribute to disorders such as Parkinson’s disease. We performed an analysis of polyphenol content, biochemical attributes and neurobiological activity of extracts from wild blueberries native to Newfoundland and Labrador. Fruits and leaves of samples contained several polyphenolic compounds, such as anthocyanins, and demonstrated high antioxidant capacity. Cell cultures of microglia, the innate immune cells of the brain, were exposed to glutamate or α-synuclein in order to induce inflammatory responses, which decreased the amount of cells after 24 h. Overall, treatment of cells with fruit or leaf extracts inhibited cell death and decreased morphological criteria associated with inflammation. These results suggest that dietary intake of blueberry fruits and leaves or supplements may be protective against neurodegenerative disorders that include a neuroinflammatory component.

为了治疗神经系统疾病，牛痘中的多酚浆果可能是标准药物的有效添加。多酚可减少氧化应激和炎症，氧化过程被认为是导致帕金森氏病等疾病的原因。我们对来自纽芬兰和拉布拉多的野生蓝莓提取物的多酚含量，生化属性和神经生物学活性进行了分析。样品的果实和叶子含有几种多酚化合物，例如花青素，并显示出高抗氧化能力。小胶质细胞（大脑的先天免疫细胞）的细胞培养物暴露于谷氨酸或α-突触核蛋白，以诱导炎症反应，从而在24小时后减少细胞数量。总体而言，用果实或叶子提取物处理细胞可抑制细胞死亡并降低与炎症相关的形态学标准。