BACKGROUND Cognitive impairment in methamphetamine (MA) users with psychosis may be more severe than that in MA users without psychosis. This study aimed to compare the overall cognitive function and specific cognitive domains between MA users with and without psychosis. METHODS Participants in this cross-sectional study were adult inpatients who used MA within the month prior to admission. The recent use of MA was confirmed using quantitative analysis of hair. We used the Mini International Neuropsychiatric Interview (MINI) - Plus, Psychotic Module to confirm the presence of recent psychosis in the participants who fulfilled the inclusion criteria, excluding the individuals with a lifetime history of schizophrenia. We assessed the severity of depression and MA withdrawal using the Patient Health Questionnaire (PHQ-9) and the Amphetamine Withdrawal Questionnaire. The severity of cognitive impairment was assessed using the Montreal Cognitive Assessment (MoCA). The MoCA total and subtest scores were used to compare participants with and without psychosis. RESULTS Participants included 113 MA users with psychosis and 120 MA users without psychosis. Those with psychosis had significantly lower MoCA total, visuaospatial/executive subtest, and abstract subtest scores than those without psychosis (mean differences=-0.8, -0.3, and -0.2, respectively). The association between MA psychosis and the MoCA total scores was still statistically significant after the adjustment for years in education in an ordinal logistic regression analysis. CONCLUSIONS MA users with psychosis had poorer overall cognitive function than MA users without psychosis. The cognitive impairment is prominent in the domains of visuospatial/executive function and abstraction.

中文翻译：

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最近有精神病的甲基苯丙胺使用者的认知障碍：泰国的一项横断面研究。

背景技术患有精神病的甲基苯丙胺（MA）使用者的认知障碍可能比没有精神病的MA使用者严重。这项研究旨在比较有和没有精神病的MA用户之间的总体认知功能和特定的认知领域。方法这项横断面研究的参与者为入院前一个月内使用MA的成年住院患者。通过对头发的定量分析证实了MA的最新用途。我们使用了迷你国际神经精神病学访谈（MINI）-加上精神病学模块，以确认符合入选标准的参与者中是否存在近期精神病，但不包括具有精神分裂症终生史的患者。我们使用患者健康调查表（PH​​Q-9）和苯丙胺戒断调查表评估了抑郁和MA戒断的严重程度。使用蒙特利尔认知评估（MoCA）评估认知障碍的严重程度。MoCA总分和子测验分数用于比较有无精神病的参与者。结果参与者包括113位精神病患者和120位无精神病患者。患有精神病的人的MoCA总分，视觉空间/执行子测验和抽象子测验的得分显着低于没有精神病的人（均值分别为-0.8，-0.3和-0.2）。经序数逻辑回归分析调整了多年的教育后，MA精神病与MoCA总分之间的关​​联仍具有统计学意义。结论患有精神病的MA使用者的整体认知功能较没有精神病的MA使用者差。认知障碍在视觉空间/执行功能和抽象领域尤为突出。