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Real and Imagined Grasping Movements Differently Activate the Human Dorsomedial Parietal Cortex.
Neuroscience ( IF 3.3 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.neuroscience.2020.03.019
Valentina Sulpizio 1 , Anna Neri 2 , Patrizia Fattori 3 , Claudio Galletti 3 , Sabrina Pitzalis 4 , Gaspare Galati 5
Affiliation  

Object prehension typically includes a transport phase (reaching) and a grip phase (grasping). Within the posterior parietal cortex (PPC), grasping movements have been traditionally associated to a lateral activation, although recent monkey evidence suggests also a medial involvement. Here, we wanted to determine whether grasping-related activities are present in the human dorsomedial parietal cortex, by focusing on two cortical regions specialized in the monkey in controlling limb movements, i.e., V6A (composed by its ventral and dorsal sectors, V6Av and V6Ad, respectively) and PEc, both recently defined also in humans. We acquired functional magnetic resonance images while participants performed both real (pantomimed) and imagined grasping of visually-presented objects. We found that the human areas V6Ad (hV6Ad) and PEc (hPEc) were both activated by real grasping, whereas hV6Ad only was activated by the imagery of grasping movements. hV6Av was not involved in either types of grasping. These results speak against the traditional notion of a medial-to-lateral segregation of reaching versus grasping information within the PPC and strengthen the idea that the human dorsomedial parietal cortex implements the whole complex pattern of visuomotor transformations required for object-oriented actions. Our findings suggest that hV6Ad is particularly involved in implementing all the visuomotor transformations needed to create an abstract representation of the object-directed action, while hPEc is involved in implementing the sensorimotor transformations needed to actually perform that action.

中文翻译:

真实的和想像的抓握动作不同地激活了人类背顶叶顶皮层。

物体抓握通常包括运输阶段(到达)和抓握阶段(抓握)。传统上,在后顶叶皮层(PPC)内,抓紧动作与侧向激活相关,尽管最近的猴子证据也表明内侧受累。在这里,我们要通过关注猴子专门控制两个肢体运动的两个皮质区域,即V6A(由其腹侧和背侧部分,V6Av和V6Ad组成),来确定人背顶顶皮质中是否存在与抓握相关的活动。和PEc,两者最近也在人类中定义。我们获得了功能性磁共振图像,而参与者同时进行了真实(虚拟)和想象中的视觉呈现物体的抓取。我们发现人类区域V6Ad(hV6Ad)和PEc(hPEc)都通过真实的抓握来激活,而hV6Ad仅通过抓握动作的图像来激活。hV6Av不参与任何一种类型的抓取。这些结果违背了在PPC内达到和掌握信息的内侧到外侧隔离的传统观念,并强化了这样的观念,即人类背顶顶皮层实现了面向对象动作所需的视觉运动转换的整个复杂模式。我们的研究结果表明,hV6Ad特别参与实现创建对象定向动作的抽象表示所需的所有视觉运动转换,而hPEc参与实现实际执行该动作所需的感觉运动转换。而hV6Ad仅由抓取动作的图像激活。hV6Av不参与任何一种类型的抓取。这些结果违背了在PPC内达到和掌握信息的内侧到外侧隔离的传统观念,并强化了这样的观念,即人类背顶顶皮层实现了面向对象动作所需的视觉运动转换的整个复杂模式。我们的研究结果表明,hV6Ad特别参与实现创建对象定向动作的抽象表示所需的所有视觉运动转换,而hPEc参与实现实际执行该动作所需的感觉运动转换。而hV6Ad仅由抓取动作的图像激活。hV6Av不参与任何一种类型的抓取。这些结果违背了在PPC内达到和掌握信息的内侧到外侧隔离的传统观念,并强化了这样的观念,即人类背顶顶皮层实现了面向对象动作所需的视觉运动转换的整个复杂模式。我们的研究结果表明,hV6Ad特别参与实现创建对象定向动作的抽象表示所需的所有视觉运动转换,而hPEc参与实现实际执行该动作所需的感觉运动转换。这些结果违背了在PPC内达到和掌握信息的内侧到外侧隔离的传统观念,并强化了这样的观念,即人类背顶顶皮层实现了面向对象动作所需的视觉运动转换的整个复杂模式。我们的研究结果表明,hV6Ad特别参与实现创建对象定向动作的抽象表示所需的所有视觉运动转换,而hPEc参与实现实际执行该动作所需的感觉运动转换。这些结果违背了在PPC内达到和掌握信息的内侧到外侧隔离的传统观念,并强化了这样的观念,即人类背顶顶皮层实现了面向对象动作所需的视觉运动转换的整个复杂模式。我们的研究结果表明,hV6Ad特别参与实现创建对象定向动作的抽象表示所需的所有视觉运动转换,而hPEc参与实现实际执行该动作所需的感觉运动转换。
更新日期:2020-03-19
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