The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

中文翻译：

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并非所有的HLA表位错配都相等。

固体器官移植中HLA匹配的未来在于表位匹配。Sapir-Pichhadze等人的文章。提供了间接证据，证明抗体验证的小片段与未验证的小片段之间的免疫原性存在差异。但是，对于HLA II类而言，这种差异尚不十分清楚，这表明需要付出更多的努力来鉴定真正具有免疫原性的II类HLA表位错配。