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Additive manufacturing for bone tissue engineering scaffolds
Materials Today Communications ( IF 3.7 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.mtcomm.2020.101024
Huawei Qu

Large bone defects, which occur due to various causes, have substantially affected people's health and quality of life. Bone tissue engineering (BTE) is a promising approach for repairing or replacing bone injuries. The aim of BTE scaffolds is to mimic the biological function and structure of the natural bone extracellular matrix (ECM), which provides a three-dimensional (3D) environment for cell adsorption, proliferation and differentiation. Significant advances in materials science, computer-aided design (CAD) and biomedical engineering have facilitated BTE scaffolds. This paper describes the requirements of BTE scaffolds and highlights the important role of additive manufacturing (AM) technologies in building bridges between biomaterials, CAD models and additives, and BTE scaffolds. It reviews various AM technologies that are used to fabricate BTE scaffolds. These technologies are divided into seven categories: (1) stereolithography (SLA), (2) powder bed fusion (PBF), (3) binder jetting (BJ), (4) material extrusion (ME), (5) material jetting (MJ), (6) volumetric printing (VP) and (7) 4D printing (4DP). The characteristics, raw materials, accuracy, cost, advantages and disadvantages of the AM technologies are discussed. Several recommendations for future research are presented.



中文翻译:

骨组织工程支架的增材制造

由于各种原因而导致的大骨缺损已严重影响了人们的健康和生活质量。骨组织工程学(BTE)是修复或替代骨损伤的一种有前途的方法。BTE支架的目的是模仿天然骨细胞外基质(ECM)的生物学功能和结构,它为细胞吸附,增殖和分化提供三维(3D)环境。材料科学,计算机辅助设计(CAD)和生物医学工程学的重大进步促进了BTE支架的发展。本文介绍了BTE支架的要求,并重点介绍了增材制造(AM)技术在构建生物材料,CAD模型和添加剂以及BTE支架之间的桥梁方面的重要作用。它回顾了用于制造BTE支架的各种AM技术。这些技术分为七个类别:(1)立体光刻(SLA),(2)粉末床熔合(PBF),(3)粘合剂喷射(BJ),(4)材料挤压(ME),(5)材料喷射( MJ),(6)体积打印(VP)和(7)4D打印(4DP)。讨论了增材制造技术的特点,原材料,精度,成本,优缺点。提出了一些未来研究的建议。讨论了AM技术的优缺点。提出了一些未来研究的建议。讨论了AM技术的优缺点。提出了一些未来研究的建议。

更新日期:2020-03-19
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